Introduction：Basic information about CAS 37000-20-7|Zinterol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Zinterol |
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| CAS Number | 37000-20-7 | Molecular Weight | 378.48600 |
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| Density | 1.282g/cm3 | Boiling Point | 574.3ºC at 760mmHg |
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| Molecular Formula | C19H26N2O4S | Melting Point | / |
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| MSDS | / | Flash Point | 301.1ºC |
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Names
| Name | N-[2-hydroxy-5-[1-hydroxy-2-[(2-methyl-1-phenylpropan-2-yl)amino]ethyl]phenyl]methanesulfonamide |
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| Synonym | More Synonyms |
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Zinterol BiologicalActivity
| Description | Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
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| Target | β2-adrenoceptor[1] |
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| In Vivo | Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits[3]. Animal Model: In New Zealand White HF rabbits of either sex[3] Dosage: 1.0 or 2.5 μg/kg Administration: Intravenous bolus administration; over 5 seconds Result: 2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits. 2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits. |
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| References | [1]. Gwee MC, et al. Pharmacological actions of a new -adrenoceptor agonist, MJ-9184-1, in anaesthetized cats. Br J Pharmacol. 1972 Nov;46(3):375-85. [2]. Skeberdis VA, et al. Beta-2 adrenergic activation of L-type Ca2+ current in cardiac myocytes. J Pharmacol Exp Ther. 1997 Nov;283(2):452-61. [3]. Desantiago J, et al. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97. |
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Chemical & Physical Properties
| Density | 1.282g/cm3 |
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| Boiling Point | 574.3ºC at 760mmHg |
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| Molecular Formula | C19H26N2O4S |
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| Molecular Weight | 378.48600 |
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| Flash Point | 301.1ºC |
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| Exact Mass | 378.16100 |
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| PSA | 107.04000 |
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| LogP | 3.95270 |
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| Index of Refraction | 1.615 |
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| InChIKey | XJBCFFLVLOPYBV-UHFFFAOYSA-N |
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| SMILES | CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c(NS(C)(=O)=O)c1 |
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| Storage condition | -20°C |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2935009090 |
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Customs
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Synonyms
| ZINTEROL |
| MJ-9184-1 |
| Zinterolum |
| Allopregnanolone |
