CAS 37558-16-0|Phorbol-12
| Common Name | Phorbol-12 | ||
|---|---|---|---|
| CAS Number | 37558-16-0 | Molecular Weight | 504.61200 |
| Density | 1.27g/cm3 | Boiling Point | 623.4ºC at 760mmHg |
| Molecular Formula | C28H40O8 | Melting Point | / |
| MSDS | USA | Flash Point | 199.3ºC |
Names
| Name | phorbol 12,13-dibutanoate |
|---|---|
| Synonym | More Synonyms |
Phorbol-12 BiologicalActivity
| Description | Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Epigenetics >>PKCResearch Areas >>CancerSignaling Pathways >>TGF-beta/Smad >>PKC |
| Target | PKC[1] |
| In Vitro | Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (1 MM) activates PKC and inhibited Na/K-ATPase transport activity in OK cells[3]. |
| References | [1]. Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25. [2]. Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269(44):27159-62. [3]. Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268(21):15958-64. |
Chemical & Physical Properties
| Density | 1.27g/cm3 |
|---|---|
| Boiling Point | 623.4ºC at 760mmHg |
| Molecular Formula | C28H40O8 |
| Molecular Weight | 504.61200 |
| Flash Point | 199.3ºC |
| Exact Mass | 504.27200 |
| PSA | 130.36000 |
| LogP | 2.63210 |
| Appearance of Characters | powder | clear, light yellow, film |
| Index of Refraction | 1.574 |
| InChIKey | BQJRUJTZSGYBEZ-YVQNUNKESA-N |
| SMILES | CCCC(=O)OC1C(C)C2(O)C(C=C(CO)CC3(O)C(=O)C(C)=CC32)C2C(C)(C)C12OC(=O)CCC |
| Storage condition | −20°C |
| Water Solubility | H2O: 30 μM |
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | 2928 |
| WGK Germany | 3 |
| RTECS | EK7767000 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
Articles49
More Articles| A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors. J. Biol. Chem. 290 , 14107-19, (2015) Anchoring proteins direct protein kinases and phosphoprotein phosphatases toward selected substrates to control the efficacy, context, and duration of neuronal phosphorylation events. The A-kinase anc... | |
| Charge density influences C1 domain ligand affinity and membrane interactions. ChemBioChem. 15(8) , 1131-44, (2014) The C1 domain, which represents the recognition motif on protein kinase C for the lipophilic second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters, has emerged as a promisi... | |
| Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway. Mol. Carcinog. 54(2) , 134-47, (2015) Rat mammary carcinoma susceptibility 5a1 (Mcs5a1), which is concordant to human MCS5A1 breast cancer risk locus, mediates susceptibility by a non-mammary cell-autonomous mechanism associated with T ce... |
Synonyms
| PDBU |
| PHORBOL 12,13-DIBUTYRATE,4BETA |
| MFCD00036783 |
| Phorbol 12,13-dibutanoate |
| Phorbol 12,13-dibutyrate,(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diylbutanoicacidester |
| Phorbol 12,13-dibutyrate |
