Introduction：Basic information about CAS 5845-67-0|(3S)-3-Isobutyl-2,5-piperazinedione, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (3S)-3-Isobutyl-2,5-piperazinedione |
|---|
| CAS Number | 5845-67-0 | Molecular Weight | 170.209 |
|---|
| Density | 1.0±0.1 g/cm3 | Boiling Point | 442.9±38.0 °C at 760 mmHg |
|---|
| Molecular Formula | C8H14N2O2 | Melting Point | 255ºC |
|---|
| MSDS | USA | Flash Point | 207.4±26.9 °C |
|---|
Names
| Name | cyclo(-leu-gly) |
|---|
| Synonym | More Synonyms |
|---|
(3S)-3-Isobutyl-2,5-piperazinedione BiologicalActivity
| Description | Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias[1][2]. |
|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
|---|
| Target | Dopamine Receptor |
|---|
| In Vivo | Cyclo(glycyl-L-leucyl) (8 mg/kg; 皮下给药) 在阿扑吗啡 (APO) 后 24 小时给予，可减弱由急性高剂量 APO (5 mg/kg; 皮下给药) 引起的 DA 受体超敏反应[1]。 Animal Model: Male Swiss-Webster mice, 20-25g[1] Dosage: 8 mg/kg Administration: SC; single dose given 24h after apomorphine (APO) Result: Attenuated the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.). |
|---|
| References | [1]. J Z Fields, et al. The effects of cyclo(leucyl-glycyl) on nigrostriatal dopaminergic supersensitivity--inhibition of apomorphine-induced climbing. Neuropeptides. 1990 Aug;16(4):207-11. [2]. H N Bhargava, et al. Cyclo (leucylglycine) inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rats. Life Sci. 1980 Jul 14;27(2):117-23. |
|---|
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|
| Boiling Point | 442.9±38.0 °C at 760 mmHg |
|---|
| Melting Point | 255ºC |
|---|
| Molecular Formula | C8H14N2O2 |
|---|
| Molecular Weight | 170.209 |
|---|
| Flash Point | 207.4±26.9 °C |
|---|
| Exact Mass | 170.105530 |
|---|
| PSA | 58.20000 |
|---|
| LogP | -0.66 |
|---|
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
|---|
| Index of Refraction | 1.453 |
|---|
| InChIKey | VQFHWKRNHGHZTK-LURJTMIESA-N |
|---|
| SMILES | CC(C)CC1NC(=O)CNC1=O |
|---|
Synonyms
| L-Leucylglycine diketopiperazine |
| MORPHINE TOLERANCE PEPTIDE |
| (3S)-3-Isobutyl-2,5-piperazinedione |
| 2,5-Piperazinedione, 3-(2-methylpropyl)-, (3S)- |
| MORPHIN,TOLERANCE PEPTIDE |
| Cyclo(Leu-Gly) |
| 3-isobutylpiperazine-2,5-quinone |
| (3S)-3-Isobutylpiperazine-2,5-dione |
