Introduction：Basic information about CAS 4176-97-0|14-Deoxyandrographolide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 14-Deoxyandrographolide |
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| CAS Number | 4176-97-0 | Molecular Weight | 334.45000 |
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| Density | 1.15g/cm3 | Boiling Point | 509.5ºC at 760 mmHg |
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| Molecular Formula | C20H30O4 | Melting Point | 176-178ºC |
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| MSDS | USA | Flash Point | 177.3ºC |
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Names
| Name | 3-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethy l-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5H)-furanone |
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| Synonym | More Synonyms |
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14-Deoxyandrographolide BiologicalActivity
| Description | 14-Deoxyandrographolide, a bioactive compound of Andrographis paniculata, has hepatoprotective efficacy. 14-Deoxyandrographolide desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| References | [1]. Roy DN, et al. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Br J Pharmacol. 2010 Aug;160(7):1823-43. |
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Chemical & Physical Properties
| Density | 1.15g/cm3 |
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| Boiling Point | 509.5ºC at 760 mmHg |
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| Melting Point | 176-178ºC |
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| Molecular Formula | C20H30O4 |
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| Molecular Weight | 334.45000 |
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| Flash Point | 177.3ºC |
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| Exact Mass | 334.21400 |
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| PSA | 66.76000 |
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| LogP | 2.99180 |
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| Index of Refraction | 1.551 |
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| InChIKey | GVRNTWSGBWPJGS-YSDSKTICSA-N |
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| SMILES | C=C1CCC2C(C)(CO)C(O)CCC2(C)C1CCC1=CCOC1=O |
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| Storage condition | 2-8℃ |
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Synonyms
| 20-ethyl-7,8-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-one |
| 14-Dehydro-browniin |
| 14-Dehydrobrowniine |
| Aconitan-14-one,20-ethyl-7,8-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-,(1alpha,6beta,16beta) |
| 14-deoxy andrographolide |
| Dehydrobrowniin |
| 10-Dehydro-browniin |
| 3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxyl-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl)furan-2(5H)-one |
| Deoxyandrographolide |
