Introduction：Basic information about CAS 63758-79-2|Indalpine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Indalpine |
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| CAS Number | 63758-79-2 | Molecular Weight | 228.33300 |
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| Density | 1.07 g/cm3 | Boiling Point | 405.1ºC at 760 mmHg |
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| Molecular Formula | C15H20N2 | Melting Point | / |
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| MSDS | / | Flash Point | 198.8ºC |
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Names
| Name | 3-(2-piperidin-4-ylethyl)-1H-indole |
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| Synonym | More Synonyms |
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Indalpine BiologicalActivity
| Description | Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>Serotonin Transporter |
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| In Vivo | In keeping with its potent reuptake-blocking property, acute IV Indalpine produces a marked decrease in the firing rate of dorsal raphe 5-HT neurons (ED50 0.33 mg/kg). The firing rate of dorsal raphe 5-HT neurons is assessed following 2-, 7- and 14-day treatments with Indalpine (5 mg/day IP). After 2 days, the firing rate of 5-HT neurons is greatly reduced, after 7 days it has recovered partially and after 14 days it has returned to normal[2]. |
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| References | [1]. R Samanin, et al. Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology (Berl). 1980;68(1):99-104. [2]. P Blier, et al. Effects of the two antidepressant drugs mianserin and Indalpine on the serotonergic system: single-cell studies in the rat. Psychopharmacology (Berl). 1984;84(2):242-9. |
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Chemical & Physical Properties
| Density | 1.07 g/cm3 |
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| Boiling Point | 405.1ºC at 760 mmHg |
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| Molecular Formula | C15H20N2 |
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| Molecular Weight | 228.33300 |
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| Flash Point | 198.8ºC |
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| Exact Mass | 228.16300 |
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| PSA | 27.82000 |
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| LogP | 3.42890 |
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| Index of Refraction | 1.595 |
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| InChIKey | SADQVAVFGNTEOD-UHFFFAOYSA-N |
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| SMILES | c1ccc2c(CCC3CCNCC3)c[nH]c2c1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NM1303800
- CHEMICAL NAME :
- 1H-Indole, 3-(2-(4-piperidinyl)ethyl)-
- CAS REGISTRY NUMBER :
- 63758-79-2
- BEILSTEIN REFERENCE NO. :
- 0612584
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C15-H20-N2
- MOLECULAR WEIGHT :
- 228.37
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 500 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 221,263,1989
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Safety Information
| RIDADR | UN 3249 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| EINECS 264-445-4 |
| Lipstene |
| INDALPINE |
| LM 5008 |
