Introduction：Basic information about CAS 81720-10-7|dinophysistoxin-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | dinophysistoxin-1 |
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| CAS Number | 81720-10-7 | Molecular Weight | 819.02900 |
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| Density | 1.27g/cm3 | Boiling Point | 923.3ºC at 760 mmHg |
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| Molecular Formula | C45H70O13 | Melting Point | / |
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| MSDS | / | Flash Point | 267.9ºC |
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Names
| Name | 9,10-deepithio-9,10-didehydro-35-methyl-acanthifolicin |
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| Synonym | More Synonyms |
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dinophysistoxin-1 BiologicalActivity
| Description | Dinophysistoxin 1 (DTX 1, 35-methylokadaic acid) is a causative agent of diarrhetic shellfish poisoning. Dinophysistoxin 1 exerts tumor-promoting activity, serves as a skin irritant as well[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | Dinophysistoxin 1 抑制特定的 [3H] 冈田酸与小鼠表皮颗粒部分的结合[1]。 |
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| In Vivo | Dinophysistoxin 1 (5 μg/mouse; 涂抹在背部; 每周 2 次, 共 30 周) 导致 100 μg 7,12-二甲基苯蒽 (DMBA) 处理组的荷瘤小鼠比例增加[1]。 |
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| References | [1]. Fujiki H, et al. Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin. Jpn J Cancer Res. 1988 Oct;79(10):1089-93. |
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Chemical & Physical Properties
| Density | 1.27g/cm3 |
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| Boiling Point | 923.3ºC at 760 mmHg |
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| Molecular Formula | C45H70O13 |
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| Molecular Weight | 819.02900 |
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| Flash Point | 267.9ºC |
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| Exact Mass | 818.48200 |
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| PSA | 182.83000 |
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| LogP | 5.45960 |
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| Index of Refraction | 1.581 |
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| InChIKey | CLBIEZBAENPDFY-WXUIFJBTSA-N |
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| SMILES | C=C1C(O)C2OC3(CCC(C=CC(C)C4CC(C)=CC5(OC(CC(C)(O)C(=O)O)CCC5O)O4)O3)CCC2OC1C(O)CC(C)C1OC2(CCC1C)OCCCC2C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AA8227820
- CHEMICAL NAME :
- Acanthifolicin, 9,10-deepithio-9,10-didehydro-35-methyl-
- CAS REGISTRY NUMBER :
- 81720-10-7
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C45-H70-O13
- MOLECULAR WEIGHT :
- 819.15
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 mg/kg/30W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
- REFERENCE :
- JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 79,1089,1988
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Synonyms
| 9,10-deepithio-9,10-didehydro-35-methyl-acanthifolici |
| (35R)-9,45-Seco-10-demercapto-9,10-didehydro-35-methylacanthifolicin |
| DINOPHYSISTOXIN-I |
| 35-methylokadaicacid |
| DTX1 |
| OKADAIC ACID,35-METHYL |
| Acanthifolicin,9,10-deepithio-9,10-didehydro-35-methyl |
| DINOPHYSISTOXIN-1 |
