CAS 3306-62-5|2-Aminobenzenesulfonamide
Introduction：Basic information about CAS 3306-62-5|2-Aminobenzenesulfonamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Aminobenzenesulfonamide | ||
|---|---|---|---|
| CAS Number | 3306-62-5 | Molecular Weight | 172.205 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 392.7±44.0 °C at 760 mmHg |
| Molecular Formula | C6H8N2O2S | Melting Point | 155-157 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 191.3±28.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-Aminobenzenesulfonamide |
|---|---|
| Synonym | More Synonyms |
2-Aminobenzenesulfonamide BiologicalActivity
| Description | 2-Aminobenzenesulfonamide is a carbonic anhydrase IX inhibitor. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Carbonic AnhydraseResearch Areas >>Cancer |
| Target | carbonic anhydrase IX[1] |
| References | [1]. Vullo D, et al. Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1005-9. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 392.7±44.0 °C at 760 mmHg |
| Melting Point | 155-157 °C(lit.) |
| Molecular Formula | C6H8N2O2S |
| Molecular Weight | 172.205 |
| Flash Point | 191.3±28.4 °C |
| Exact Mass | 172.030655 |
| PSA | 94.56000 |
| LogP | 0.22 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.628 |
| InChIKey | YAZSBRQTAHVVGE-UHFFFAOYSA-N |
| SMILES | Nc1ccccc1S(N)(=O)=O |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 10,319,1937 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84518 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 168 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S36/37/39-S26-S22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DA9449000 |
| HS Code | 2935009090 |
Customs
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
Articles3
More Articles| Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety. Bioorg. Med. Chem. 16(6) , 2955-67, (2008) Inhibition of the hepatitis C virus (HCV) NS3 protease has emerged as an attractive approach to defeat the global hepatitis C epidemic. In this work, we present the synthesis and biochemical evaluatio... | |
| Nitrogen-15 nuclear magnetic resonance study of benzenesulfonamide and cyanate binding to carbonic anhydrase. Biochemistry 22 , 2658, (1983) | |
| Heterocycles with a benzothiadiazepine moiety. 5. Derivatives of pyrrolo[2,1-d][1,2,5]benzothiadiazepine, a novel tricyclic ring. Il Farmaco 52(6-7) , 375-8, (1997) The synthesis of pyrrolo[2,1-d][1,2,5]benzothiadiazepin-7(6H)-one 5,5-dioxide has been achieved by reaction between 2-(1H-pyrrol-1-yl)benzenesulfonamide and triphosgene. N-Ethylation of the tricyclic ... |
Synonyms
| 2-Aminobenzenesulfonamide |
| orthanilamide |
| aminobenzenesulfonamide |
| 2-Sulphamoylaniline |
| EINECS 221-988-1 |
| MFCD08443599 |
| sulfamoylaniline |
| o-sulfanilamide |
| 2-amino-benzenesulfonamid |
| Benzenesulfonamide, 2-amino- |
| o-amino-benzenesulfonamid |
| 2-Aminobenzenesulfonamde |
| 2-Amino-Benzensulfonamide |
| o-aminobenzenesulfonamide |
| 2-Aminobenzenesulfamide |
