Introduction：Basic information about CAS 580-22-3|2-Aminoquinoline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Aminoquinoline is a promising compound as bioavailable nNOS inhibitor but suffers from low human nNOS inhibition, low selectivity versus human eNOS, and significant binding to other CNS targets. 2-Aminoquinoline has the potential for the research of antineurodegenerative agents[1].
Related Catalog
Signaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Neurological Disease
References
[1]. Pensa AV, et al. Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. J Med Chem. 2017;60(16):7146-7165.
Chemical & Physical Properties
Density
1.2±0.1 g/cm3
Boiling Point
304.9±15.0 °C at 760 mmHg
Melting Point
125 °C
Molecular Formula
C9H8N2
Molecular Weight
144.17
Flash Point
163.6±7.6 °C
Exact Mass
144.068741
PSA
38.91000
LogP
1.73
Vapour Pressure
0.0±0.6 mmHg at 25°C
Index of Refraction
1.708
InChIKey
GCMNJUJAKQGROZ-UHFFFAOYSA-N
SMILES
Nc1ccc2ccccc2n1
Water Solubility
soluble
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
VA9621800
CHEMICAL NAME :
Quinoline, 2-amino-
CAS REGISTRY NUMBER :
580-22-3
BEILSTEIN REFERENCE NO. :
0113163
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H8-N2
MOLECULAR WEIGHT :
144.19
WISWESSER LINE NOTATION :
T66 BNJ CZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
500 nmol/plate
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 42,861,1978
Safety Information
Symbol
GHS05, GHS07
Signal Word
Danger
Hazard Statements
H302-H315-H318-H335
Precautionary Statements
P261-P280-P305 + P351 + P338
Hazard Codes
Xn: Harmful;
Risk Phrases
R20/21/22;R36/37/38
Safety Phrases
S26-S36/37/39-S22
RIDADR
NONH for all modes of transport
RTECS
VA9621800
HS Code
2933499090
Customs
HS Code
2933499090
Summary
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles1
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