CAS 34096-83-8|Glycyrrhetic acid 3-O-mono-beta-D-glucuronide

Introduction：Basic information about CAS 34096-83-8|Glycyrrhetic acid 3-O-mono-beta-D-glucuronide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameGlycyrrhetic acid 3-O-mono-beta-D-glucuronide
CAS Number34096-83-8Molecular Weight646.80800
Density1.31g/cm3Boiling Point785ºC at 760mmHg
Molecular FormulaC36H54O10Melting Point/
MSDS/Flash Point240.7ºC

Names

Name(2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
SynonymMore Synonyms

BiologicalActivity

DescriptionGlycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity[1]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β‐glucuronidases (β‐GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG[2].Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
In VitroGlycyrrhetic acid 3-O-β-D-glucuronide can inhibit the release of β‐hexosaminidase from RBL‐2H3 cells with an IC50 value of 0.28 mM[2]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) significantly reduces the nitrite concentration in a dose-dependent manner with an IC50 value of 120 μM in LPS‐induced RAW264.7 cells[2].
References

[1]. Park HY,et al. Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.Arch Pharm Res. 2004 Jan;27(1):57-60.

[2]. Lichun Guo,et al. Glycyrrhetic Acid 3‐O‐Mono‐β‐d‐glucuronide (GAMG): An Innovative High‐Potency Sweetener with Improved Biological Activities. Comprehensive Reviews in Food Science and Food Safety 

Chemical & Physical Properties

Density1.31g/cm3
Boiling Point785ºC at 760mmHg
Molecular FormulaC36H54O10
Molecular Weight646.80800
Flash Point240.7ºC
Exact Mass646.37200
PSA170.82000
LogP4.32910
InChIKeyHLDYLAJAWSKPFZ-QDPIGISRSA-N
SMILESCC1(C(=O)O)CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(OC6OC(C(=O)O)C(O)C(O)C6O)C(C)(C)C5CCC43C)C2C1

Synonyms

Glycyrrhetyl 3-monoglucuronide
Glycyrrhetic Acid 3-O-Glucuronide
3-monoglucuronylglycyrrhetinic acid
Starrhizin
3-MGA
glycyrrhetic acid mono-glucuronide
Glycyrrhetinic acid 3-O-mono-beta-D-glucuronide
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