Introduction：Basic information about CAS 477-19-0|(7α)-9,10-Dimethoxy-1-methyllycorenan-7-ol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (7α)-9,10-Dimethoxy-1-methyllycorenan-7-ol |
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| CAS Number | 477-19-0 | Molecular Weight | 317.379 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 477.7±45.0 °C at 760 mmHg |
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| Molecular Formula | C18H23NO4 | Melting Point | 199-200ºC |
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| MSDS | / | Flash Point | 242.7±28.7 °C |
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Names
| Name | lycorenine |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Lycorenine is an alkaloid that has vasodepressor action. Lycorenine also exhibits anticancer and antibacterial activities[1][2][3]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Lycorenine inhibits the cell viability, with IC50s of 0.8 and 1.2 μg/mL for LMTK and HEPG2 cells, respectively[2]. |
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| In Vivo | Lycorenine (1-10 mg/kg i.v.) produces dose-related decreases in blood pressure and heart rate in anesthetized rats[1]. |
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| References | [1]. Miyasaka K, et, al. Pharmacological studies of lycorenine, an alkaloid of Lycoris radiata Herb.: Vasodepressor mechanism in rats. Jpn J Pharmacol. 1979 Aug;29(4):605-22. [2]. Weniger B, et, al. Cytotoxic activity of Amaryllidaceae alkaloids. Planta Med. 1995 Feb;61(1):77-9. [3]. Gu D, et, al. Antibacterial Phytosterols and Alkaloids from Lycoris radiate. Natural Product Sciences. 2014 Jou; 20(2): 107-112. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 477.7±45.0 °C at 760 mmHg |
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| Melting Point | 199-200ºC |
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| Molecular Formula | C18H23NO4 |
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| Molecular Weight | 317.379 |
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| Flash Point | 242.7±28.7 °C |
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| Exact Mass | 317.162720 |
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| PSA | 51.16000 |
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| LogP | 2.39 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.617 |
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| InChIKey | VHYYSQODIQWPDO-PILAGYSTSA-N |
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| SMILES | COc1cc2c(cc1OC)C1C(CC=C3CCN(C)C31)OC2O |
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| Storage condition | 2-8°C |
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Synonyms
| [2]Benzopyrano[3,4-g]indol-7-ol, 1,2,3,5,5a,7,11b,11c-octahydro-9,10-dimethoxy-1-methyl-, (5aR,7S,11bS,11cS)- |
| ycorenine |
| (7α)-9,10-Dimethoxy-1-methyllycorenan-7-ol |
