CAS 79-55-0|Pempidine

Introduction：Basic information about CAS 79-55-0|Pempidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pempidine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles28
8. Synonyms

Common Name	Pempidine
CAS Number	79-55-0	Molecular Weight	155.28000
Density	0.858 g/mL at 25 °C(lit.)	Boiling Point	187-188 °C(lit.)
Molecular Formula	C₁₀H₂₁N	Melting Point	137-141ºC
MSDS	ChineseUSA	Flash Point	122 °F
Symbol	GHS02, GHS06	Signal Word	Danger

Names

Name	1,2,2,6,6-pentamethylpiperidine
Synonym	More Synonyms

Pempidine BiologicalActivity

Description	Pempidine is a ganglion-blocking drug, introduced as an oral treatment for hypertension.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. Martin TJ, et al. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine. J Pharmacol Exp Ther. 1990 Jul;254(1):45-51. [2]. L. BRETHERICK, Congeners of Pempidine with High Ganglion-blocking Activity. Nature, 1959, 184: 1707-1709 )

Description

Pempidine is a ganglion-blocking drug, introduced as an oral treatment for hypertension.

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. Martin TJ, et al. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine. J Pharmacol Exp Ther. 1990 Jul;254(1):45-51.

[2]. L. BRETHERICK, Congeners of Pempidine with High Ganglion-blocking Activity. Nature, 1959, 184: 1707-1709 )

Chemical & Physical Properties

Density	0.858 g/mL at 25 °C(lit.)
Boiling Point	187-188 °C(lit.)
Melting Point	137-141ºC
Molecular Formula	C₁₀H₂₁N
Molecular Weight	155.28000
Flash Point	122 °F
Exact Mass	155.16700
PSA	3.24000
LogP	2.59720
Index of Refraction	n20/D 1.460(lit.)
InChIKey	XULIXFLCVXWHRF-UHFFFAOYSA-N
SMILES	CN1C(C)(C)CCCC1(C)C
Storage condition	Flammables area

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN2190000

CHEMICAL NAME :: Piperidine, 1,2,2,6,6-pentamethyl-

CAS REGISTRY NUMBER :: 79-55-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H21-N

MOLECULAR WEIGHT :: 155.32

WISWESSER LINE NOTATION :: T6NTJ A1 B1 B1 F1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 184,1707,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 184,1707,1959

Safety Information

Symbol	GHS02, GHS06
Signal Word	Danger
Hazard Statements	H226-H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R10
Safety Phrases	S26-S36/37
RIDADR	UN 1992 3/PG 3
WGK Germany	3
RTECS	TN2190000
Packaging Group	III
Hazard Class	3
HS Code	2933399090

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles28

Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes.

Neurochem. Res. 21(9) , 1141-8, (1996)

The modulation of [3H]ACh release by nicotinic compounds was studied in superfused rat hippocampal synaptosomes loaded with [3H]choline, (-)-Nicotine (0.1-10 microM) evoked a dose-dependent increase i...

Enhancement of naturally occurring cell death in the sympathetic and parasympathetic ganglia of the chicken embryo following blockade of ganglionic transmission.

Brain Res. 444(1) , 189-94, (1988)

Both presynaptic and postsynaptic blockade of ganglionic transmission during the period of naturally occurring ganglion cell death reduced the number of surviving neurons in the sympathetic ganglia (S...

Understanding channel blocking in the nicotinic acetylcholine receptor.

Receptors Channels 7(4) , 273-88, (2001)

Ion-channel blockers are molecules that obstruct the path used by ions to cross the membrane through a protein channel. Many of these are local anesthetics, toxins or drugs of abuse, and the knowledge...

Synonyms

PIPERIDINE,1,2,2,6,6-PENTAMETHYL

Pyrilene

MFCD00006493

N-methyl-2,2,6,6-tetramethylpiperidine

Perolysen

EINECS 201-211-2

M+B 4486

Pempidine

N,2,2,6,6-pentamethyl piperidine

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