CAS 188627-80-7|Eptifibatide acetate salt

Introduction：Basic information about CAS 188627-80-7|Eptifibatide acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Eptifibatide acetate salt BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Eptifibatide acetate salt
CAS Number	188627-80-7	Molecular Weight	831.962
Density	1.6±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₃₅H₄₉N₁₁O₉S₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	eptifibatide
Synonym	More Synonyms

Eptifibatide acetate salt BiologicalActivity

Description	Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.Target: OthersEptifibatide is an anti-coagulant that selectively blocks the platelet glycoprotein IIb/IIIa receptor. Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarus barbouri). It belongs to the class of the so called arginin-glycin-aspartat-mimetics and reversibly binds to platelets [1, 2].
Related Catalog	Signaling Pathways >>Cytoskeleton >>IntegrinResearch Areas >>Cardiovascular DiseasePeptides
References	[1]. Amoroso, G., et al., Eptifibatide and abciximab exhibit equivalent antiplatelet efficacy in an experimental model of stenting in both healthy volunteers and patients with coronary artery disease. J Cardiovasc Pharmacol, 2001. 38(4): p. 633-41. [2]. Schwarz, M., et al., Reversibility versus persistence of GPIIb/IIIa blocker-induced conformational change of GPIIb/IIIa (alphaIIbbeta3, CD41/CD61). J Pharmacol Exp Ther, 2004. 308(3): p. 1002-11.

Description

Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.Target: OthersEptifibatide is an anti-coagulant that selectively blocks the platelet glycoprotein IIb/IIIa receptor. Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarus barbouri). It belongs to the class of the so called arginin-glycin-aspartat-mimetics and reversibly binds to platelets [1, 2].

Related Catalog

Signaling Pathways >>Cytoskeleton >>IntegrinResearch Areas >>Cardiovascular DiseasePeptides

References

[1]. Amoroso, G., et al., Eptifibatide and abciximab exhibit equivalent antiplatelet efficacy in an experimental model of stenting in both healthy volunteers and patients with coronary artery disease. J Cardiovasc Pharmacol, 2001. 38(4): p. 633-41.

[2]. Schwarz, M., et al., Reversibility versus persistence of GPIIb/IIIa blocker-induced conformational change of GPIIb/IIIa (alphaIIbbeta3, CD41/CD61). J Pharmacol Exp Ther, 2004. 308(3): p. 1002-11.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Molecular Formula	C₃₅H₄₉N₁₁O₉S₂
Molecular Weight	831.962
Exact Mass	831.315613
PSA	374.49000
LogP	-4.84
Index of Refraction	1.735
InChIKey	KWKBRYJYRIUYEI-QMYFOHRPSA-N
SMILES	CC(=O)O.NC(=O)C1CSSCCC(=O)NC(CCCCN=C(N)N)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)N2CCCC2C(=O)N1
Storage condition	-20°C

Synonyms

[(3R,11S,17S,20S,25aS)-11-(4-Carbamimidamidobutyl)-3-carbamoyl-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid

Integrilin

7H-Pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosine-17-acetic acid, 3-(aminocarbonyl)-11-[4-[(aminoiminomethyl)amino]butyl]docosahydro-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxo-, (3R,11S,17S,20S,25aS)-

Eptifibatide

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