CAS 63283-36-3|Calcifediol
| Common Name | Calcifediol | ||
|---|---|---|---|
| CAS Number | 63283-36-3 | Molecular Weight | 418.65 |
| Density | / | Boiling Point | 529.2ºC at 760 mmHg |
| Molecular Formula | C27H46O3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 221.4ºC |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | Vitamin D3 25-hydroxy monohydrate |
|---|---|
| Synonym | More Synonyms |
Calcifediol BiologicalActivity
| Description | Calcifediol (monohydrate) is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM). |
|---|---|
| Related Catalog | Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Metabolic Disease |
| In Vitro | Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival[1]. |
| References | [1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22. |
Chemical & Physical Properties
| Boiling Point | 529.2ºC at 760 mmHg |
|---|---|
| Molecular Formula | C27H46O3 |
| Molecular Weight | 418.65 |
| Flash Point | 221.4ºC |
| PSA | 40.46000 |
| LogP | 6.73390 |
| Vapour Pressure | 2.07E-13mmHg at 25°C |
| InChIKey | WRLFSJXJGJBFJQ-NVQSLZSUSA-N |
| SMILES | C=C1CCC(O)CC1=CC=C1CCCC2(C)C1CCC2C(C)CCCC(C)(C)O.O |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H319 |
| Precautionary Statements | P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+:Very toxic |
| Risk Phrases | R28 |
| Safety Phrases | 28-36/37-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
Articles55
More Articles| Silver dopants for targeted and untargeted direct analysis of unsaturated lipids via infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI). Rapid Commun. Mass Spectrom. 28(22) , 2461-70, (2014) Unsaturated lipids play a crucial role in cellular processes as signaling factors, membrane building blocks or energy storage molecules. However, adequate mass spectrometry imaging of this diverse gro... | |
| Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry. J. Chromatogr. A. 1364 , 214-22, (2014) We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of... | |
| Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular research. Biomed. Chromatogr. 28(6) , 913-7, (2014) The accurate and specific measurement of vitamin D is increasingly important for determining the role of vitamin D in the pathogenesis of disease. Liquid chromatography coupled to tandem mass spectrom... |
Synonyms
| MFCD00867077 |
| 1H-Indene-1-pentanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-α,α,ε,7a-tetramethyl-, (εR,1R,3aS,4E,7aR)-, hydrate (1:1) |
| EINECS 242-990-9 |
| Calcifediol hydrate |
| (3S,5Z,7E)-9,10-Secocholesta-5,7,10-triene-3,25-diol hydrate (1:1) |
| Calcifediol (monohydrate) |
| Calcifediol |
