Introduction：Basic information about CAS 633-35-2|1,4,6-androstatrien-3,17-dione, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1,4,6-androstatrien-3,17-dione |
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| CAS Number | 633-35-2 | Molecular Weight | 282.377 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 452.8±45.0 °C at 760 mmHg |
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| Molecular Formula | C19H22O2 | Melting Point | 164-165ºC |
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| MSDS | ChineseUSA | Flash Point | 168.7±25.7 °C |
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Names
| Name | androsta-1,4,6-triene-3,17-dione |
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| Synonym | More Synonyms |
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1,4,6-androstatrien-3,17-dione BiologicalActivity
| Description | Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2]. |
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| Related Catalog | Research Areas >>EndocrinologyResearch Areas >>Neurological DiseaseSignaling Pathways >>Others >>Aromatase |
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| Target | Ki: 0.18 μM (aromatase)[1] |
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| In Vivo | Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations[2]. Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis [1]. Animal Model: Rats (220-250 g)[2] Dosage: 25 mg/kg, 100 mg/kg Administration: Subcutaneous injection Result: Prevented the normal rise in ovarian estradiol concentrations with a single injection 3 hours before the time of the estrogen surge on proestrus. |
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| References | [1]. Covey DF, et al. Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity. Endocrinology. 1981 Apr;108(4):1597-9. [2]. Brodie AM, et al. Antifertility effects of an aromatase inhibitor, 1,4,6-androstatriene-3, 17-dione. Endocrinology. 1979 Jan;104(1):118-21. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 452.8±45.0 °C at 760 mmHg |
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| Melting Point | 164-165ºC |
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| Molecular Formula | C19H22O2 |
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| Molecular Weight | 282.377 |
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| Flash Point | 168.7±25.7 °C |
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| Exact Mass | 282.161987 |
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| PSA | 34.14000 |
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| LogP | 2.52 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.587 |
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| InChIKey | DKVSUQWCZQBWCP-QAGGRKNESA-N |
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| SMILES | CC12C=CC(=O)C=C1C=CC1C2CCC2(C)C(=O)CCC12 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- BV8082250
- CHEMICAL NAME :
- Androsta-1,4,6-triene-3,17-dione
- CAS REGISTRY NUMBER :
- 633-35-2
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C19-H22-O2
- MOLECULAR WEIGHT :
- 282.41
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 260 mg/kg
- SEX/DURATION :
- female 30-55 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 51,1273,1994
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Safety Information
Synonyms
| Conchinin |
| 1,4,6-androstatrien-3,17-dione |
| QUINDINE |
| Androsta-1,4,6-triene-3,17-dione |
| Chinidin |
| androst-1,4,6-triene-3,17-dione |
| Kinidin |
| Cin-quin |
| Coccinine |
| Quinidex |
| QUNIDINE |
| PITAYINE |
| Pitayin |
| 1,4,6-Androstatriene-3,17-dione |
| Androsta-1,4,6-trien-3,17-dion |
