CAS 64769-66-0|trans-4-Carboxy-L-proline
| Common Name | trans-4-Carboxy-L-proline | ||
|---|---|---|---|
| CAS Number | 64769-66-0 | Molecular Weight | 159.14000 |
| Density | 1.456 g/cm3 | Boiling Point | 355.3ºC at 760 mmHg |
| Molecular Formula | C6H9NO4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 168.7ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (2S,4R)-pyrrolidine-2,4-dicarboxylic acid |
|---|---|
| Synonym | More Synonyms |
trans-4-Carboxy-L-proline BiologicalActivity
| Description | Trans-4-Carboxy-L-prolineis a selective glutamate transporter inhibitor[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
| References | [1]. Bridges RJ, et al. Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. J Med Chem. 1991 Feb;34(2):717-25. |
Chemical & Physical Properties
| Density | 1.456 g/cm3 |
|---|---|
| Boiling Point | 355.3ºC at 760 mmHg |
| Molecular Formula | C6H9NO4 |
| Molecular Weight | 159.14000 |
| Flash Point | 168.7ºC |
| Exact Mass | 159.05300 |
| PSA | 86.63000 |
| Index of Refraction | 1.534 |
| InChIKey | NRSBQSJHFYZIPH-DMTCNVIQSA-N |
| SMILES | O=C(O)C1CNC(C(=O)O)C1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles28
More Articles| Evidence for a role of GABA- and glutamate-gated chloride channels in olfactory memory. Pharmacol. Biochem. Behav. 103(1) , 69-75, (2012) In the honeybee, we investigated the role of transmissions mediated by GABA-gated chloride channels and glutamate-gated chloride channels (GluCls) of the mushroom bodies (MBs) on olfactory learning us... | |
| Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors. Bioorg. Med. Chem. Lett. 16(12) , 3268-72, (2006) A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC50 = 2-250 nM) with selec... | |
| The effects of local perfusion of DAMGO on extracellular GABA and glutamate concentrations in the rostral ventromedial medulla. J. Neurochem. 104(3) , 806-17, (2008) Electrophysiological data suggest an involvement of rostral ventromedial medulla (RVM) GABA and glutamate (GLU) neurons in morphine analgesia. Direct evidence that extracellular concentrations of GABA... |
Synonyms
| L-trans-pyrrolidine-2,4-dicarboxylic acid |
| MFCD00153866 |
| Quipazine dimaleate |
| trans-4-Carboxy-L-proline |
| t-2,4-PDC |
| L-trans-PDC |
| t-PDC |
