CAS 107390-08-9|Garcinone D

Introduction：Basic information about CAS 107390-08-9|Garcinone D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameGarcinone D
CAS Number107390-08-9Molecular Weight428.475
Density1.304Boiling Point674.2±55.0 °C at 760 mmHg
Molecular FormulaC24H28O7Melting Point202-204 ºC
MSDS/Flash Point231.2±25.0 °C

Names

Name1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methylbut-2-enyl)xanthen-9-one
SynonymMore Synonyms

Garcinone D BiologicalActivity

DescriptionGarcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners[1].
Related CatalogSignaling Pathways >>Stem Cell/Wnt >>STATSignaling Pathways >>NF-κB >>Keap1-Nrf2Signaling Pathways >>JAK/STAT Signaling >>STATResearch Areas >>Neurological Disease
Target

p-STAT3

References

[1]. Yang X, et al. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Neurosci Lett. 2016 Jul 28;626:6-12.

Chemical & Physical Properties

Density1.304
Boiling Point674.2±55.0 °C at 760 mmHg
Melting Point202-204 ºC
Molecular FormulaC24H28O7
Molecular Weight428.475
Flash Point231.2±25.0 °C
Exact Mass428.183502
PSA120.36000
LogP3.71
Vapour Pressure0.0±2.2 mmHg at 25°C
Index of Refraction1.625
InChIKeyTYALNCRUIKOKGP-UHFFFAOYSA-N
SMILESCOc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CCC(C)(C)O

Safety Information

Hazard CodesXi

Synonyms

1,3,6-Trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
Garcinone D
9H-Xanthen-9-one, 1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-butenyl)-
9H-Xanthen-9-one, 1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-buten-1-yl)-
1,3,6-Trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
9H-Xanthen-9-one,1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-butenyl)
CAS 76996-27-5|Garcinone C
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