Introduction：Basic information about CAS 70588-05-5|Obtusin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Obtusin |
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| CAS Number | 70588-05-5 | Molecular Weight | 344.315 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 614.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C18H16O7 | Melting Point | / |
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| MSDS | / | Flash Point | 227.0±25.0 °C |
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Names
| Name | Obtusin |
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| Synonym | More Synonyms |
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Obtusin BiologicalActivity
| Description | Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression[1]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological Disease |
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| Target | IC50: 11.12 μM (hMAO-A)[1] Ki: 6.15 (hMAO-A)[1] |
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| References | [1]. Paudel P, et al. In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds. ACS Omega. 2019 Sep 18;4(14):16139-16152. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 614.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C18H16O7 |
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| Molecular Weight | 344.315 |
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| Flash Point | 227.0±25.0 °C |
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| Exact Mass | 344.089600 |
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| PSA | 102.29000 |
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| LogP | 4.10 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.634 |
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| InChIKey | CFLNHFUPWNRWJA-UHFFFAOYSA-N |
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| SMILES | COc1cc2c(c(O)c1OC)C(=O)c1c(cc(C)c(O)c1OC)C2=O |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2914690090 |
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| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl- |
| 1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione |
| 1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone |
