Introduction：Basic information about CAS 477-85-0|Obtusifolin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Obtusifolin |
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| CAS Number | 477-85-0 | Molecular Weight | 284.263 |
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| Density | 1.448±0.06 g/cm3 | Boiling Point | 528.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H12O5 | Melting Point | 242-243ºC |
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| MSDS | / | Flash Point | 202.2±23.6 °C |
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Names
| Name | 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione |
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| Synonym | More Synonyms |
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Obtusifolin BiologicalActivity
| Description | Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2]. |
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| Related Catalog | Research Areas >>Cancer |
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| Target | NF-κB |
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| In Vitro | Obtusifolin (1, 10, 100 μM) inhibits MUC5AC gene expression induced by EGF, PMA, or TNF-α in NCI-H292 cells[1]. |
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| References | [1]. Choi BS, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway. Phytother Res. 2019 Apr;33(4):919-928. [2]. Hsu YL, et al. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem. 2014 Dec 10;62(49):11933-40. |
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Chemical & Physical Properties
| Density | 1.448±0.06 g/cm3 |
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| Boiling Point | 528.0±50.0 °C at 760 mmHg |
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| Melting Point | 242-243ºC |
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| Molecular Formula | C16H12O5 |
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| Molecular Weight | 284.263 |
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| Flash Point | 202.2±23.6 °C |
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| Exact Mass | 284.068481 |
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| PSA | 83.83000 |
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| LogP | 4.18 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.678 |
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| InChIKey | NYRXUBDGDSRBGB-UHFFFAOYSA-N |
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| SMILES | COc1c(O)c(C)cc2c1C(=O)c1c(O)cccc1C2=O |
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| Storage condition | -20℃ |
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| Water Solubility | Insuluble (2.6E-3 g/L) (25 ºC) |
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Synonyms
| Anthraquinone,2,8-dihydroxy-1-methoxy-3-methyl |
| 2,8-dihydroxy-1-methoxy-3-methyl-anthraquinone |
| Anthraquinone, 2,8-dihydroxy-1-methoxy-3-methyl- |
| 9,10-Anthracenedione, 2,8-dihydroxy-1-methoxy-3-methyl- |
| 2,8-Dihydroxy-1-methoxy-3-methyl-anthrachinon |
| obtusifoline |
| Obtusifolin (anthraquinone) |
| 1,7-Dihydroxy-8-methoxy-6-methyl-9,10-anthraquinone |
| 2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthraquinone |
| Obtusifolin |
| 2,8-dihydroxy-1-methoxy-3-methylanhraquinone |
| 2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione |
