Introduction：Basic information about CAS 77449-94-6|(4R)-4-Hydroxy-D-proline hydrochloride (1:1), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (4R)-4-Hydroxy-D-proline hydrochloride (1:1) |
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| CAS Number | 77449-94-6 | Molecular Weight | 167.591 |
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| Density | / | Boiling Point | 368.6ºC at 760 mmHg |
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| Molecular Formula | C5H10ClNO3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | cis-4-Hydroxy-D-proline Hydrochloride |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Boiling Point | 368.6ºC at 760 mmHg |
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| Molecular Formula | C5H10ClNO3 |
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| Molecular Weight | 167.591 |
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| Exact Mass | 167.034927 |
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| PSA | 69.56000 |
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| InChIKey | YEJFFQAGTXBSTI-VKKIDBQXSA-N |
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| SMILES | Cl.O=C(O)C1CC(O)CN1 |
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| Storage condition | 2~8℃ |
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Safety Information
| Hazard Codes | Xi |
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| Safety Phrases | 24/25-36-26 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| (4R)-4-Hydroxy-D-proline hydrochloride (1:1) |
| (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid,hydrochloride |
| D-Proline, 4-hydroxy-, (4R)-, hydrochloride (1:1) |
