Introduction：Basic information about CAS 77094-11-2|MeIQ, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MeIQ |
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| CAS Number | 77094-11-2 | Molecular Weight | 212.25000 |
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| Density | 1.36g/cm3 | Boiling Point | 465.7ºC at 760 mmHg |
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| Molecular Formula | C12H12N4 | Melting Point | 291-293ºC |
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| MSDS | / | Flash Point | 235.4ºC |
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Names
| Name | 3,4-dimethylimidazo[4,5-f]quinolin-2-amine |
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| Synonym | More Synonyms |
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MeIQ BiologicalActivity
| Description | Me-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | Me-IQ (Methyl-IQ; 含0.04% 或0.01% 的饮食) 导致小鼠前胃鳞状细胞癌和乳头状瘤的发生率很高。0.04% 剂量组的 Me-IQ 诱发的前胃鳞状细胞癌中约40% 转移至肝脏[1]。 |
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| References | [1]. H Ohgaki, et al. Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx. Princess Takamatsu Symp. 1985;16:97-105. [2]. T Aune, et al. Mutagenic activation of IQ and Me-IQ by liver and lung microsomes from rabbit and mouse, and with isolated lung cells from the rabbit. Carcinogenesis. 1986 Feb;7(2):273-6. |
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Chemical & Physical Properties
| Density | 1.36g/cm3 |
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| Boiling Point | 465.7ºC at 760 mmHg |
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| Melting Point | 291-293ºC |
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| Molecular Formula | C12H12N4 |
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| Molecular Weight | 212.25000 |
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| Flash Point | 235.4ºC |
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| Exact Mass | 212.10600 |
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| PSA | 56.73000 |
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| LogP | 2.59330 |
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| Index of Refraction | 1.725 |
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| InChIKey | GMGWMIJIGUYNAY-UHFFFAOYSA-N |
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| SMILES | Cc1cc2ncccc2c2nc(N)n(C)c12 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NJ5907000
- CHEMICAL NAME :
- 3H-Imidazo(4,5-f)quinoline, 2-amino-3,4-dimethyl-
- CAS REGISTRY NUMBER :
- 77094-11-2
- LAST UPDATED :
- 199807
- DATA ITEMS CITED :
- 30
- MOLECULAR FORMULA :
- C12-H12-N4
- MOLECULAR WEIGHT :
- 212.28
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5040 mg/kg/40W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Endocrine - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7476 mg/kg/89W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 22120 mg/kg/81W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27888 mg/kg/83W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Morphological transformation
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA - TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - guinea pig Lung
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,245,1985 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993
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Safety Information
| Hazard Codes | T: Toxic; |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Methyl IQ |
| Me IQ |
| 3,4-dimethyl-3H-imidazo<quinolin-2-amine |
| MelQ |
| 2-amino-3,4-dimethylimidazo<4,5-f>quinoline |
