CAS 78454-17-8|7-Epi-10-deacetyltaxol

Introduction：Basic information about CAS 78454-17-8|7-Epi-10-deacetyltaxol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 7-Epi-10-deacetyltaxol BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	7-Epi-10-deacetyltaxol
CAS Number	78454-17-8	Molecular Weight	811.86900
Density	1.41±0.1 g/cm3 (20 ºC 760 Torr)	Boiling Point	959.5℃ at 760 mmHg
Molecular Formula	C₄₅H₄₉NO₁₃	Melting Point	163-170?C
MSDS	/	Flash Point	/

Names

Name	10-deacetyltaxol
Synonym	More Synonyms

7-Epi-10-deacetyltaxol BiologicalActivity

Description	7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>Others
References	[1]. Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2). [2]. Dang PH, et al.α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana. J Nat Prod. 2017 Apr 28;80(4):1087-1095.

Description

7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM[1][2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Others >>Others

References

[1]. Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2).

[2]. Dang PH, et al.α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana. J Nat Prod. 2017 Apr 28;80(4):1087-1095.

Chemical & Physical Properties

Density	1.41±0.1 g/cm3 (20 ºC 760 Torr)
Boiling Point	959.5℃ at 760 mmHg
Melting Point	163-170?C
Molecular Formula	C₄₅H₄₉NO₁₃
Molecular Weight	811.86900
Exact Mass	811.32000
PSA	218.71000
LogP	3.73970
InChIKey	TYLVGQKNNUHXIP-DIYBZAJCSA-N
SMILES	CC(=O)OC12COC1CC(O)C1(C)C(=O)C(O)C3=C(C)C(OC(=O)C(O)C(NC(=O)c4ccccc4)c4ccccc4)CC(O)(C(OC(=O)c4ccccc4)C21)C3(C)C
Storage condition	-20°C Freezer, Under Inert Atmosphere
Water Solubility	Insuluble (2.4E-4 g/L) (25 ºC)

Safety Information

Hazard Codes	Xi
RIDADR	NONH for all modes of transport

Synonyms

Ormosin VI

10-Desacetyl-7-epipaclitaxel

10-Deacetyl-7-epi-taxol

7-Epi-10-deacetyltaxol

7-Epi 10-Desacetyl Paclitaxel

CS-1143

10-Deacetyl-7-epi-paclitaxel

7-Epi-10-deacetyl-taxol

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