CAS 641-77-0|11beta,17alpha-dihydroxy-4-pregnene-3,20-dione
| Common Name | 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione | ||
|---|---|---|---|
| CAS Number | 641-77-0 | Molecular Weight | 346.46100 |
| Density | 1.21g/cm3 | Boiling Point | 523.9ºC at 760 mmHg |
| Molecular Formula | C21H30O4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 284.7ºC |
| Symbol | GHS02, GHS06, GHS08 | Signal Word | Danger |
Names
| Name | 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia[1]. |
|---|---|
| Related Catalog | Research Areas >>Endocrinology |
| Target | Human Endogenous Metabolite |
| References | [1]. Franks RC. Plasma 17-hydroxyprogesterone, 21-deoxycortisol and cortisol in congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1974;39(6):1099-1102. |
Chemical & Physical Properties
| Density | 1.21g/cm3 |
|---|---|
| Boiling Point | 523.9ºC at 760 mmHg |
| Molecular Formula | C21H30O4 |
| Molecular Weight | 346.46100 |
| Flash Point | 284.7ºC |
| Exact Mass | 346.21400 |
| PSA | 74.60000 |
| LogP | 2.80920 |
| Index of Refraction | 1.576 |
| InChIKey | LCZBQMKVFQNSJR-UJPCIWJBSA-N |
| SMILES | CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C |
| Storage condition | ?20°C |
Safety Information
| Symbol | GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
Articles28
More Articles| An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism. J. Steroid Biochem. Mol. Biol. 145 , 75-84, (2015) Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/M... | |
| Hirsutism and acne in women: coordinated radioimmunoassays for eight relevant plasma steroids. Clin. Chem. 40(12) , 2296-305, (1994) We developed and validated a coordinated set of RIAs for the following eight steroids in single small aliquots (< or = 1 mL) of plasma: androstenedione, dehydroepiandrosterone, 11-deoxycortisol, 21-de... | |
| Superior discriminating value of ACTH-stimulated serum 21-deoxycortisol in identifying heterozygote carriers for 21-hydroxylase deficiency. Clin. Endocrinol. (Oxf.) 73(6) , 700-6, (2010) Congenital adrenal hyperplasia caused by classic 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder with a high prevalence of asymptomatic heterozygote carriers (HTZ) in the general ... |
Synonyms
| 21-deoxycortisol |
| 21-Deoxyhydrocortisone |
| 21-Dehydrohydrocortisone |
| 21-DESOXYCORTISOL |
| 21 DEOXYCORTISOL 21-DESOXYCORTISOL |
| 4-pregnene-11-B-17-A-diol-3-20-dione |
| 4-Pregnen-11,17a-diol-3,20-dione-d8 |
| EINECS 211-375-7 |
