Introduction：Basic information about CAS 478-01-3|Nobiletin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nobiletin |
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| CAS Number | 478-01-3 | Molecular Weight | 402.395 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 587.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H22O8 | Melting Point | 138 °C |
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| MSDS | ChineseUSA | Flash Point | 256.5±30.2 °C |
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Names
| Name | nobiletin |
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| Synonym | More Synonyms |
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Nobiletin BiologicalActivity
| Description | Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>CancerNatural Products >>Flavonoids |
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| References | [1]. Takito J, et al. Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells. Can J Physiol Pharmacol. 2016 Feb 12:1-6. [2]. He B, et al. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21. [3]. Cheng HL, et al. Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 2016 Apr 29. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 587.9±50.0 °C at 760 mmHg |
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| Melting Point | 138 °C |
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| Molecular Formula | C21H22O8 |
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| Molecular Weight | 402.395 |
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| Flash Point | 256.5±30.2 °C |
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| Exact Mass | 402.131470 |
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| PSA | 85.59000 |
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| LogP | 2.48 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.558 |
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| InChIKey | MRIAQLRQZPPODS-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2)cc1OC |
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| Storage condition | -20°C |
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| Stability | Stable, but unstable if heated rapidly. Combustible. Incompatible with strong oxidizing agents, powdered aluminium, potassium. |
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Safety Information
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36/37/39 |
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Synonyms
| 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one |
| 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy- |
| Flavone, 5,6,7,8,3',4'-hexamethoxy |
| Nobiletin,Hexamethoxyflavone |
| 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one |
| Nobiletin |
| 3',4',5,6,7,8-hexamethoxy-flavone |
| 5,6,7,8,3',4'-Hexamethoxyflavone |
| 3',4',5,6,7,8-Hexamethoxyflavone |
| Hexamethoxyflavone |
| MFCD03273560 |
| 2-(3,4-dimethoxy-phenyl)-5,6,7,8-tetramethoxy-chromen-4-one |
