CAS 63-39-8|Uridine triphosphate

Introduction：Basic information about CAS 63-39-8|Uridine triphosphate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Uridine triphosphate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Synonyms

Common Name	Uridine triphosphate
CAS Number	63-39-8	Molecular Weight	484.14100
Density	2.106 g/cm3	Boiling Point	/
Molecular Formula	C₉H₁₅N₂O₁₅P₃	Melting Point	/
MSDS	/	Flash Point	113ºC

Names

Name	utp
Synonym	More Synonyms

Uridine triphosphate BiologicalActivity

Description	Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a pyrimidine nucleoside triphosphate that participates in glycogen metabolism and synthesis of RNA during transcription.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>CancerResearch Areas >>Cardiovascular DiseaseResearch Areas >>Inflammation/Immunology
In Vitro	Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression[1]. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K[2].
In Vivo	Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function[3]. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes[4].
Cell Assay	Pancreatic duct epithelial cells are treated with (0.1 μM-1 mM) uridine triphosphate. BrdU is added after different time points (12-24 hours). Proliferation is measured using the BrdU incorporation assay in triplicate[2].
Animal Admin	Rats: Four main groups are tested: (1) sham without LAD ligation, (2) LAD ligation, (3) injected with UTP (0.44 µg/kg i.v.) 30 min before MI, (4) UTP injection (4.4 µg/kg i.v.) 24 h prior to MI. Several different concentrations of UTP are tested (0.044–44.4 µg/kg). Left ventricular systolic pressure (LVSP), end-diastolic pressure (LVEDP) and heart rates are monitored before, after UTP treatment and post MI[3].
References	[1]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998. [2]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6. [3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55. [4]. Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5'-triphosphate in mice. Microbes Infect. 2014 Mar;16(3):196-202.

Chemical & Physical Properties

Density	2.106 g/cm3
Molecular Formula	C₉H₁₅N₂O₁₅P₃
Molecular Weight	484.14100
Flash Point	113ºC
Exact Mass	483.96900
PSA	293.80000
InChIKey	PGAVKCOVUIYSFO-XVFCMESISA-N
SMILES	O=c1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)[nH]1
Storage condition	−20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU8083000

CHEMICAL NAME :: Uridine, 5'-(tetrahydrogen triphosphate)

CAS REGISTRY NUMBER :: 63-39-8

BEILSTEIN REFERENCE NO. :: 0071520

LAST UPDATED :: 199701

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H15-N2-O15-P3

MOLECULAR WEIGHT :: 484.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 1 mmol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,52,1975

Safety Information

Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	22-26-36
WGK Germany	1

Synonyms

uridine-triphosphate

Uteplex

[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

Uridine 5'-triphosphoric acid

uridine 5'-O-triphosphate

MFCD00274571

5'-UTP

uridine 5'-triphosphate

EINECS 243-347-5

Uridine triphosphate

Uridine 5'-(tetrahydrogen triphosphate)

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