Introduction：Basic information about CAS 65666-07-1|Silymarin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Silymarin |
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| CAS Number | 65666-07-1 | Molecular Weight | 482.436 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 793.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C25H22O10 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 274.5±26.4 °C |
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Names
| Name | silymarin |
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| Synonym | More Synonyms |
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Silymarin BiologicalActivity
| Description | Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC)[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| References | [1]. Féher J, et al. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr Pharm Biotechnol. 2012 Jan;13(1):210-7. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 793.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C25H22O10 |
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| Molecular Weight | 482.436 |
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| Flash Point | 274.5±26.4 °C |
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| Exact Mass | 482.121307 |
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| PSA | 155.14000 |
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| LogP | 2.59 |
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| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
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| Index of Refraction | 1.684 |
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| InChIKey | SEBFKMXJBCUCAI-DBMPWETRSA-N |
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| SMILES | COc1cc(C2Oc3cc(C4Oc5cc(O)cc(O)c5C(=O)C4O)ccc3OC2CO)ccc1O |
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| Storage condition | −20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VW5503000
- CHEMICAL NAME :
- Silymarin
- CAS REGISTRY NUMBER :
- 65666-07-1
- LAST UPDATED :
- 199709
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- REFERENCE :
- RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 61,273,1988
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Safety Information
| Safety Phrases | S22-S24/25 |
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| WGK Germany | 3 |
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| HS Code | 3003909090 |
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Customs
Synonyms
| Silymarin + Melatonin |
| (2R,3R)-3,5,7-Trihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one |
| Silymarin P.E. |
| MILK THISTLE |
| EINECS 245-302-5 |
| Silymarin |
| Silybum marianum |
| Legalon |
| silibum marianum extract |
| 4H-1-Benzopyran-4-one, 2-[(2S,3S)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- |
| Legalon 70 |
| MFCD01776359 |
