Introduction：Basic information about CAS 5092-09-1|Saikogenin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Saikogenin A |
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| CAS Number | 5092-09-1 | Molecular Weight | 472.700 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 607.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H48O4 | Melting Point | / |
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| MSDS | / | Flash Point | 252.4±26.1 °C |
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Names
| Name | (3S,4R,4aR,6aR,6bS,8S,8aS,14aS,14bS)-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicene-3,8-diol |
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| Synonym | More Synonyms |
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Saikogenin A BiologicalActivity
| Description | Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Dipeptidyl PeptidaseResearch Areas >>Metabolic DiseaseResearch Areas >>Inflammation/ImmunologyNatural Products >>Terpenoids and Glycosides |
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| Target | DPP-IV[1] |
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| In Vitro | Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide[1]. |
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| In Vivo | Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation[2]. |
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| References | [1]. Pharmaceutical application of saikogenin A. CN107375300A. [2]. Cheng JT, et al. Anti-inflammatory effect of Saikogenin A. Biochem Pharmacol. 1986 Aug 1;35(15):2483-7. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 607.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H48O4 |
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| Molecular Weight | 472.700 |
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| Flash Point | 252.4±26.1 °C |
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| Exact Mass | 472.355255 |
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| PSA | 80.92000 |
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| LogP | 5.38 |
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| Vapour Pressure | 0.0±3.9 mmHg at 25°C |
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| Index of Refraction | 1.586 |
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| InChIKey | QGNVMEXLLPGQEV-HSFRRAFJSA-N |
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| SMILES | CC1(C)CCC2(CO)C(=C3C=CC4C5(C)CCC(O)C(C)(CO)C5CCC4(C)C3(C)CC2O)C1 |
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Synonyms
| Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,16β)- |
| (3β,4α,16β)-Oleana-11,13(18)-diene-3,16,23,28-tetrol |
| saikogenin A |
| (3β,16β)-Oleana-11,13(18)-diene-3,16,23,28-tetrol |
