Introduction：Basic information about CAS 29307-03-7|Deoxyelephantopin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Deoxyelephantopin |
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| CAS Number | 29307-03-7 | Molecular Weight | 344.358 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 584.3±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H20O6 | Melting Point | 150-153℃ |
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| MSDS | Chinese | Flash Point | 258.1±30.2 °C |
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Names
| Name | Elephantopus carolinianus compd. B |
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| Synonym | More Synonyms |
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Deoxyelephantopin BiologicalActivity
| Description | Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| Target | NF-κB |
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| In Vitro | Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC50s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively[1]. Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells[1]. |
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| References | [1]. Farha Arakkaveettil Kabeer, et al. Molecular Mechanisms of Anticancer Activity of Deoxyelephantopin in Cancer Cells. Integr Med Res. 2017 Jun;6(2):190-206. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 584.3±50.0 °C at 760 mmHg |
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| Melting Point | 150-153℃ |
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| Molecular Formula | C19H20O6 |
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| Molecular Weight | 344.358 |
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| Flash Point | 258.1±30.2 °C |
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| Exact Mass | 344.125977 |
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| PSA | 78.90000 |
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| LogP | 1.51 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.556 |
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| InChIKey | JMUOPRSXUVOHFE-UXBLZVDNSA-N |
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| SMILES | C=C(C)C(=O)OC1CC2=CC(CC(C)=CC3OC(=O)C(=C)C31)OC2=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LY4250000
- CAS REGISTRY NUMBER :
- 29307-03-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C19-H20-O6
- MOLECULAR WEIGHT :
- 344.39
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 2143 umol/L
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1235,1978
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Safety Information
Synonyms
| Deoxyelephantopin |
| (3S,4R,8R,9Z,12R)-10-Methyl-5-methylene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.0]pentadeca-1(15),9-dien-3-yl methacrylate |
| 2-Propenoic acid, 2-methyl-, (3aR,4S,9R,11Z,12aR)-2,3,3a,4,5,9,10,12a-octahydro-11-methyl-3-methylene-2,7-dioxo-7H-9,6-methenofuro[2,3-f]oxacycloundecin-4-yl ester |
| Isodeoxyelephantopin |
