CAS 187389-53-3|Boc-D-FMK
| Common Name | Boc-D-FMK | ||
|---|---|---|---|
| CAS Number | 187389-53-3 | Molecular Weight | 263.263 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 383.5±37.0 °C at 760 mmHg |
| Molecular Formula | C11H18FNO5 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 185.7±26.5 °C |
Names
| Name | Boc-Asp(OMe)-fluoromethyl ketone |
|---|---|
| Synonym | More Synonyms |
Boc-D-FMK BiologicalActivity
| Description | Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>CaspaseResearch Areas >>Inflammation/Immunology |
| Target | Caspase |
| In Vitro | Boc-Asp(OME)-Fluoromethyl Keton (100 μM; 30 minutes; Polymorphonuclear leukocytes) prevents Fas-induced and spontaneous apoptosis (−CH-11)[1]. Boc-Asp(OME)-Fluoromethyl Keton (20 μM; 5 hours; J774.1/JA-4 cells) significantly increases LDH release[2]. |
| References | [1]. Paunel-Görgülü A, et al. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216(3):334-342. [2]. Koike A, et al. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp Cell Res. 2019;380(2):171-179. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 383.5±37.0 °C at 760 mmHg |
| Molecular Formula | C11H18FNO5 |
| Molecular Weight | 263.263 |
| Flash Point | 185.7±26.5 °C |
| Exact Mass | 263.116913 |
| PSA | 81.70000 |
| LogP | 1.91 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.440 |
| InChIKey | MXOOUCRHWJYCAL-ZETCQYMHSA-N |
| SMILES | COC(=O)CC(NC(=O)OC(C)(C)C)C(=O)CF |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2924199090 |
Customs
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles4
More Articles| C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells. PLoS ONE 6 , e20053, (2011) Diacylglycerol (DAG)-mediated signaling pathways, such as those mediated by protein kinase C (PKC), are central in regulating cell proliferation and apoptosis. DAG-responsive C1 domains are therefore ... | |
| Caspase inhibitors promote the survival of avulsed spinal motoneurons in neonatal rats. Neuroreport 12 , 541, (2001) Following ventral root avulsion in neonatal animals, the degeneration of spinal motoneurons occurs by an apoptotic-like morphological pathway. In adult animals, however, the mechanism of degeneration ... | |
| The maternal-effect gene cellular island encodes aurora B kinase and is essential for furrow formation in the early zebrafish embryo. PLoS Genet. 5 , e1000518, (2009) Females homozygous for a mutation in cellular island (cei) produce embryos with defects in cytokinesis during early development. Analysis of the cytoskeletal events associated with furrow formation re... |
Synonyms
| Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)- |
| pentanoic acid, 3-[[(1E)-(1,1-dimethylethoxy)hydroxymethylene]amino]-5-fluoro-4-oxo-, methyl ester, (3S)- |
| caspase inhibitor3 |
| Methyl (3S)-5-fluoro-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-4-oxopentanoate |
