CAS 345957-19-9|3 3' 5-triiodo-l-thyronine sodium salt&
Introduction：Basic information about CAS 345957-19-9|3 3' 5-triiodo-l-thyronine sodium salt&, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3 3' 5-triiodo-l-thyronine sodium salt& | ||
|---|---|---|---|
| CAS Number | 345957-19-9 | Molecular Weight | 690.97100 |
| Density | / | Boiling Point | / |
| Molecular Formula | C15H13I3NNaO5 | Melting Point | 205ºC (dec.)(lit.) |
| MSDS | USA | Flash Point | / |
Names
| Name | Sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophen yl]propanoate hydrate (1:1:1) |
|---|
3 3' 5-triiodo-l-thyronine sodium salt& BiologicalActivity
| Description | Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>EndocrinologySignaling Pathways >>Others >>Thyroid Hormone Receptor |
| Target | Human Endogenous Metabolite |
| In Vitro | Liothyronine (T3, 100 nM) sodium hydrate stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine sodium hydrate binds to human β1 thyroid hormone receptor (hTRβ1), and changes its conformation. Liothyronine sodium hydrate promotes growth, induces differentiation and regualtes metabolic effects[2]. |
| References | [1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. [3]. Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. |
Chemical & Physical Properties
| Melting Point | 205ºC (dec.)(lit.) |
|---|---|
| Molecular Formula | C15H13I3NNaO5 |
| Molecular Weight | 690.97100 |
| Exact Mass | 690.78300 |
| PSA | 104.84000 |
| LogP | 5.02690 |
| InChIKey | IRGJMZGKFAPCCR-LTCKWSDVSA-M |
| SMILES | NC(Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)[O-].O.[Na+] |
| Storage condition | -20°C |
Safety Information
| Safety Phrases | S22-S24/25 |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
