Introduction：Basic information about CAS 456-12-2|Aegeline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Aegeline |
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| CAS Number | 456-12-2 | Molecular Weight | 297.348 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 567.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H19NO3 | Melting Point | 180 °C |
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| MSDS | / | Flash Point | 297.1±30.1 °C |
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Names
| Name | (E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide |
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| Synonym | More Synonyms |
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Aegeline BiologicalActivity
| Description | Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>FungalResearch Areas >>Neurological Disease |
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| In Vitro | Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein orBax-expressing cells[1]. Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin[2]. |
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| References | [1]. Derf A, et al. a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast [published correction appears in Bioorg Med Chem Lett. 2019 Aug 15;29(16):2437-2438]. Bioorg Med Chem Lett. 2019;29(3):454‐460. [2]. Nugroho AE, et al. Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells. Pak J Pharm Sci. 2011;24(3):359‐367. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 567.7±50.0 °C at 760 mmHg |
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| Melting Point | 180 °C |
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| Molecular Formula | C18H19NO3 |
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| Molecular Weight | 297.348 |
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| Flash Point | 297.1±30.1 °C |
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| Exact Mass | 297.136505 |
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| PSA | 62.05000 |
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| LogP | 2.45 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.612 |
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| InChIKey | QRFDENJATPJOKG-KPKJPENVSA-N |
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| SMILES | COc1ccc(C(O)CNC(=O)C=Cc2ccccc2)cc1 |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2924299090 |
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Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| UNII:60T59LN3SG |
| Aegelin |
| (2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylacrylamide |
| 2-Propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)- |
| 2-propenamide |
