CAS 183449-57-2|(Pyr3)-Amyloid β-Protein (3-42) ammonium salt

Introduction：Basic information about CAS 183449-57-2|(Pyr3)-Amyloid β-Protein (3-42) ammonium salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(Pyr3)-Amyloid β-Protein (3-42) ammonium salt
CAS Number	183449-57-2	Molecular Weight	4309.86
Density	/	Boiling Point	/
Molecular Formula	C₁₉₆H₂₉₉N₅₃O₅₅S	Melting Point	/
MSDS	ChineseUSA	Flash Point	/

Names

Name	[pGlu3]-Amyloid β-Protein Fragment 3-42
Synonym	More Synonyms

BiologicalActivity

Description	(Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits[1].
Related Catalog	Research Areas >>Neurological Disease
References	[1]. Takahashi-Ito K, et.al. Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates. Biochem Biophys Res Commun. 2017 Nov 4;493(1):158-163.

Chemical & Physical Properties

Molecular Formula	C₁₉₆H₂₉₉N₅₃O₅₅S
Molecular Weight	4309.86
Exact Mass	4307.19000
PSA	1722.65000
LogP	5.49010
Appearance of Characters	solid
InChIKey	KGOBZCKPDJHJMH-UHFFFAOYSA-N
SMILES	CCC(C)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CNC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(NC(=O)C(CCC(=O)O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1ccccc1)NC(=O)C1CCC(=O)N1)C(C)C)C(C)C)C(C)C)C(=O)NC(C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C)C(=O)O)C(C)CC)C(C)C)C(C)C)C(C)C)C(C)CC
Storage condition	−20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Synonyms

pyr-phe-arg-his-asp-ser-gly-tyr-glu-val-his-his-gln-lys-leu-val-phe-phe-ala-glu-asp-val-gly-ser-asn-lys-gly-ala-ile-ile-gly-leu-met-val-gly-gly-val-val-ile-ala trifluoroacetate

MFCD03457978

Pyr-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

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