CAS 330936-70-4|(Gly14)-Humanin (human) trifluoroacetate salt

Introduction：Basic information about CAS 330936-70-4|(Gly14)-Humanin (human) trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(Gly14)-Humanin (human) trifluoroacetate salt
CAS Number	330936-70-4	Molecular Weight	2657.21000
Density	/	Boiling Point	/
Molecular Formula	C₁₁₈H₂₀₂N₃₄O₃₁S₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	(gly14)-humanin (human)
Synonym	More Synonyms

BiologicalActivity

Description	(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions[1][2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Neurological Disease
In Vitro	(Gly14)-Humanin (human) (0.1-10 μM; 72 hours) 显着增加细胞活力，降低 HUVEC 的核荧光、裂解 PARP 水平、ROS 形成和 bax/bcl-2 比值。并降低 bax 的mRNA水平，增加 bcl-2 的 mRNA 水平[1]。 Cell Viability Assay[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 100 nM, 1 μM and 10 μM Incubation Time: Pretreatment 3 hours and then treated with 72 hours Result: Significantly increased cell viability. Western Blot Analysis[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 1 μM Incubation Time: Pretreatment 3 hours and then treated with 72 hours Result: Reduced the ratio of bax/bcl-2.
In Vivo	(Gly14)-Humanin (human)（0.1 μg/5 μL；i.c.v.；一次）减少受损皮层和海马体中具有质膜通透性的细胞，减少脑损伤体积，改善运动性能并改善莫里斯水迷宫试验中的性能[2]。 Animal Model: Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI)[2] Dosage: 0.1 μg/5 μL Administration: Intracerebroventricularly (i.c.v.); once Result: Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.
References	[1]. Ying Xie, et al. Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells. Diabetes Res Clin Pract. 2014 Dec;106(3):560-6. [2]. T Wang, et al. [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice. Neuroscience. 2013 Feb 12;231:70-81.

Chemical & Physical Properties

Molecular Formula	C₁₁₈H₂₀₂N₃₄O₃₁S₂
Molecular Weight	2657.21000
Exact Mass	2655.47000
PSA	1105.92000
LogP	5.41140
InChIKey	WUYRHUFIUFJVQU-XJUNAYMOSA-N
SMILES	CCC(C)C(NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(N)CCSC)C(C)O)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)O)C(C)C

Safety Information

WGK Germany	3

Synonyms

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