Introduction：Basic information about CAS 34597-40-5|Fenoprofen Calcium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fenoprofen Calcium |
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| CAS Number | 34597-40-5 | Molecular Weight | 262.31 |
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| Density | 1.183g/cm3 | Boiling Point | 381.3ºC at 760mmHg |
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| Molecular Formula | C15H14Ca0.5O3 | Melting Point | / |
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| MSDS | / | Flash Point | 141.7ºC |
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Names
| Name | fenoprofen calcium (anhydrous) |
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| Synonym | More Synonyms |
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Fenoprofen Calcium BiologicalActivity
| Description | Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.Target: Prostaglandin G/H synthase 1Fenoprofen is a non-steroidal anti-inflammatory, antipyretic, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout. Fenoprofen has a serum half-life of about 150 to 180 minutes and is at least 99% bound to plasma proteins. It is extensively metabolised after oral administration, the main metabolites being fenoprofen glucuronide and 4-hydroxy-fenoprofen glucuronide [1]. Fenoprofen calcium is revealed for relief of mild to moderate pain in adults and for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. In patients with osteoarthritis, the anti-inflammatory and analgesic effects of fenoprofen calcium have been demonstrated by decrease in tenderness as a response to pressure and reduction in night pain, stiffness, swelling, and overall disease activity. These effects have also been demonstrated by attenuation of pain with motion and at rest and increased range of motion in involved joints [2]. |
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| Related Catalog | Research Areas >>Inflammation/Immunology |
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| Target | COX |
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| References | [1]. Takashima-Hirano M, et al. General method for the (11)C-labeling of 2-arylpropionic acids and their esters: construction of a PET tracer library for a study of biological events involved in COXs expression. Chemistry. 2010 Apr 12;16(14):4250-8. |
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Chemical & Physical Properties
| Density | 1.183g/cm3 |
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| Boiling Point | 381.3ºC at 760mmHg |
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| Molecular Formula | C15H14Ca0.5O3 |
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| Molecular Weight | 262.31 |
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| Flash Point | 141.7ºC |
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| PSA | 71.06000 |
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| LogP | 7.17980 |
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| InChIKey | VHUXSAWXWSTUOD-UHFFFAOYSA-L |
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| SMILES | CC(C(=O)[O-])c1cccc(Oc2ccccc2)c1.CC(C(=O)[O-])c1cccc(Oc2ccccc2)c1.[Ca+2] |
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| Storage condition | -20℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CY1678870
- CHEMICAL NAME :
- Benzeneacetic acid, alpha-methyl-3-phenoxy-, calcium salt, (+-)-
- CAS REGISTRY NUMBER :
- 34597-40-5
- LAST UPDATED :
- 199203
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C30-H26-O6.Ca
- MOLECULAR WEIGHT :
- 522.64
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 415 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 14,4385,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 686 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Blood - changes in spleen
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 14,4385,1980
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Safety Information
Synonyms
| calciumfenoprofen |
| FENOPROFEN CALCIUM |
| Fepron |
| nalfon |
| calcium methyl-3-phenoxybenzeneacetate |
| fenoprofen-calcium dihydrate |
