CAS 78782-98-6|Calcifediol-D6

Introduction：Basic information about CAS 78782-98-6|Calcifediol-D6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Calcifediol-D6 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Calcifediol-D6
CAS Number	78782-98-6	Molecular Weight	406.67400
Density	/	Boiling Point	/
Molecular Formula	C₂₇H₃₈D₆O₂	Melting Point	64-69°C
MSDS	/	Flash Point	14℃
Symbol	GHS02, GHS07	Signal Word	Danger

Names

Name	(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
Synonym	More Synonyms

Calcifediol-D6 BiologicalActivity

Description	Calcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase IC50 value:Target: This metabolite is being measured by physicians worldwide to determine a patient's vitamin d status.Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation.
Related Catalog	Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Metabolic Disease
References	[1]. Teitelbaum SL. Calcifediol (25-hydroxyvitamin D3) in the treatment of uremic bone disease. Ann Intern Med. 1981 Mar;94(3):404-5. [2]. Kleinman LM, Letteri JM, Asad SN, Ellis KJ, Cohn SH. Effects of calcifediol on calcified tissue in uremia. Arch Intern Med. 1978 May 15;138 Spec No:864-5. [3]. Recker R, Schoenfeld P, Letteri J, Slatopolsky E, Goldsmith R, Brickman A. The efficacy of calcifediol in renal osteodystrophy. Arch Intern Med. 1978 May 15;138 Spec No:857-63. [4]. Teitelbaum SL, Bone JM, Stein PM, Gilden JJ, Bates M, Boisseau VC, Avioli LV. Calcifediol in chronic renal insufficiency. Skeletal response. JAMA. 1976 Jan 12;235(2):164-7.

Description

Calcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase IC50 value:Target: This metabolite is being measured by physicians worldwide to determine a patient's vitamin d status.Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation.

Related Catalog

Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Metabolic Disease

References

[1]. Teitelbaum SL. Calcifediol (25-hydroxyvitamin D3) in the treatment of uremic bone disease. Ann Intern Med. 1981 Mar;94(3):404-5.

[2]. Kleinman LM, Letteri JM, Asad SN, Ellis KJ, Cohn SH. Effects of calcifediol on calcified tissue in uremia. Arch Intern Med. 1978 May 15;138 Spec No:864-5.

[3]. Recker R, Schoenfeld P, Letteri J, Slatopolsky E, Goldsmith R, Brickman A. The efficacy of calcifediol in renal osteodystrophy. Arch Intern Med. 1978 May 15;138 Spec No:857-63.

[4]. Teitelbaum SL, Bone JM, Stein PM, Gilden JJ, Bates M, Boisseau VC, Avioli LV. Calcifediol in chronic renal insufficiency. Skeletal response. JAMA. 1976 Jan 12;235(2):164-7.

Chemical & Physical Properties

Melting Point	64-69°C
Molecular Formula	C₂₇H₃₈D₆O₂
Molecular Weight	406.67400
Flash Point	14℃
Exact Mass	406.37200
PSA	40.46000
LogP	6.73390
Storage condition	Amber Vial, -20°C Freezer, Under Inert Atmosphere

Safety Information

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319
Precautionary Statements	P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235
Hazard Codes	F
Risk Phrases	11
Safety Phrases	7-16
RIDADR	UN1170 - class 3 - PG 2 - Ethanol, solution

Synonyms

Hidroferol-d6

Calcidiol-d6

Calcifediol-D6

25-Hydroxyvitamin D3-d6

25-Hydroxyvitamin D-d6

Ro 8-8892-d6

<26,27-2H6>-25-hydroxyvitamin D3

Didrogyl-d6

25-Hydroxycholecalciferol-d6

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