CAS 330-55-2|Linuron
Introduction：Basic information about CAS 330-55-2|Linuron, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Linuron | ||
|---|---|---|---|
| CAS Number | 330-55-2 | Molecular Weight | 249.094 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 361.7±52.0 °C at 760 mmHg |
| Molecular Formula | C9H10Cl2N2O2 | Melting Point | 93-94°C |
| MSDS | ChineseUSA | Flash Point | 172.6±30.7 °C |
| Symbol | GHS07, GHS08, GHS09 | Signal Word | Danger |
Names
| Name | linuron |
|---|---|
| Synonym | More Synonyms |
Linuron BiologicalActivity
| Description | Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor[1][2][3][4]. |
|---|---|
| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>Others >>Androgen Receptor |
| Target | Ki: 100 μM (Androgen receptor)[2] Photosystem II[4] |
| References | [1]. Benjamin Horemans, et al. Functional Redundancy of Linuron Degradation in Microbial Communities in Agricultural Soil and Biopurification Systems. Appl Environ Microbiol. 2016 Apr 18;82(9):2843-2853. [2]. C Lambright, et al. Cellular and Molecular Mechanisms of Action of Linuron: An Antiandrogenic Herbicide That Produces Reproductive Malformations in Male Rats. Toxicol Sci. 2000 Aug;56(2):389-99. [3]. Hongwei Ding, et al. Reproductive Toxicity of Linuron Following Gestational Exposure in Rats and Underlying Mechanisms. Toxicol Lett. 2017 Jan 15;266:49-55. [4]. Elżbieta G Magnucka, et al. Various Effects of the Photosystem II--inhibiting Herbicides on 5-n-alkylresorcinol Accumulation in Rye Seedlings. Pestic Biochem Physiol. 2014 Nov;116:56-62. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 361.7±52.0 °C at 760 mmHg |
| Melting Point | 93-94°C |
| Molecular Formula | C9H10Cl2N2O2 |
| Molecular Weight | 249.094 |
| Flash Point | 172.6±30.7 °C |
| Exact Mass | 248.011932 |
| PSA | 41.57000 |
| LogP | 3.33 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.556 |
| InChIKey | XKJMBINCVNINCA-UHFFFAOYSA-N |
| SMILES | CON(C)C(=O)Nc1ccc(Cl)c(Cl)c1 |
| Water Solubility | 0.0075 g/100 mL |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1146 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 48 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 3765 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg/60D-C
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1070 mg/kg/31W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 10 gm/kg/10D-I
- TOXIC EFFECTS :
- Cardiac - EKG changes not diagnostic of specified effects Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 7500 mg/kg/30D-I
- TOXIC EFFECTS :
- Behavioral - muscle weakness Cardiac - EKG changes not diagnostic of specified effects Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - domestic
- DOSE/DURATION :
- 1750 mg/kg/7D-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Related to Chronic Data - death
- TYPE OF TEST :
- DNA damage
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,353,1978 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,353,1978 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
Safety Information
| Symbol | GHS07, GHS08, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H351-H360Df-H373-H410 |
| Precautionary Statements | P201-P273-P281-P308 + P313-P501 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | N,T,F |
| Risk Phrases | R61 |
| Safety Phrases | S53-S45-S60-S61-S36/37 |
| RIDADR | UN 3077 |
| RTECS | YS9100000 |
| HS Code | 2928000032 |
Customs
| HS Code | 2928000032 |
|---|---|
| Summary | 2928000032 3-(4-bromo-3-chlorophenyl)-1-methoxy-1-methylurea。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0% |
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| Occurrence and distribution of sulfonylurea and related herbicides in central Canadian surface waters 2006-2008. Bull. Environ. Contam. Toxicol. 87(4) , 420-5, (2011) Surface water sampling in 2006-2008 measured the occurrence of sulfonylureas and related herbicides (SUs) during base flow conditions and wet weather events. Flumetsulam (29.2%), diuron (36.5%) and fo... | |
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Synonyms
| Lorex |
| EINECS 206-356-5 |
| 3-(3,4-Dichlorophenyl)-1-methoxy-1-methylurea |
| Linuron |
| Laroks |
| Urea, N'-(3,4-dichlorophenyl)-N-methoxy-N-methyl- |
| AFALON |
| LOROX |
| MFCD00055249 |
| Afolan |
| Liron |
| Methanol, 1-[(3,4-dichlorophenyl)imino]-1-(methoxymethylamino)-, (E)- |
| LINEX |
| LINNET |
| N’-(3,4-dichlorophenyl)-N-methoxy-N-methylurea |
| LINUREX |
