Introduction：Basic information about CAS 985-12-6|Drotaverine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Drotaverine hydrochloride |
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| CAS Number | 985-12-6 | Molecular Weight | 433.968 |
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| Density | 1.097 g/cm3 | Boiling Point | 564ºC at 760 mmHg |
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| Molecular Formula | C24H32ClNO4 | Melting Point | 208-212ºC |
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| MSDS | / | Flash Point | 240.7ºC |
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Names
| Name | (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline,hydrochloride |
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| Synonym | More Synonyms |
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Drotaverine hydrochloride BiologicalActivity
| Description | Drotaverine (hydrochloride) is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelSignaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE) |
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| References | [1]. Patai Z, Guttman A, Mikus EG. Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine. Pharmacology. 2018;101(3-4):163-169. |
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Chemical & Physical Properties
| Density | 1.097 g/cm3 |
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| Boiling Point | 564ºC at 760 mmHg |
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| Melting Point | 208-212ºC |
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| Molecular Formula | C24H32ClNO4 |
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| Molecular Weight | 433.968 |
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| Flash Point | 240.7ºC |
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| Exact Mass | 433.201996 |
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| PSA | 48.95000 |
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| LogP | 6.05600 |
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| InChIKey | JBFLYOLJRKJYNV-MASIZSFYSA-N |
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| SMILES | CCOc1ccc(C=C2NCCc3cc(OCC)c(OCC)cc32)cc1OCC.Cl |
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| Storage condition | -20°C Freezer |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NX5014000
- CHEMICAL NAME :
- Isoquinoline, 1,2,3,4-tetrahydro-6,7-diethoxy-1-((3,4-diethoxypheny l)methylene)-, hydrochloride
- CAS REGISTRY NUMBER :
- 985-12-6
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C24-H31-N-O4.Cl-H
- MOLECULAR WEIGHT :
- 434.02
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 540 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 6,7,3',4'-Tetraethoxy-1-benzal-1,2,3,4-tetrahydroisoquinoline hydrochloride |
| DROTAVERINE HCL |
| DROTAVERINE HYDROCHLORIDE |
| Drotaverine HCl ;1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy 1,2,3,4-tetrahydroisoquinoline HCL |
| Drotaverinium chloride |
| Isodihydroperparine hydrochloride |
| MFCD01754602 |
| Drotaverin hydrochloride |
| Isoquinoline, 1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-, (1Z)-, hydrochloride (1:1) |
| (1Z)-1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride |
| (1Z)-1-[(3,4-Diethoxyphenyl)methyliden]-6,7-diethoxy-1,2,3,4-tetrahydroisochinolinhydrochlorid |
| Tetraspasmin-Lefa |
| (1Z)-1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1) |
| No-Spa hydrochloride |
