CAS 79794-75-5|Loratadine
| Common Name | Loratadine | ||
|---|---|---|---|
| CAS Number | 79794-75-5 | Molecular Weight | 382.883 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 531.3±50.0 °C at 760 mmHg |
| Molecular Formula | C22H23ClN2O2 | Melting Point | 134-136°C |
| MSDS | ChineseUSA | Flash Point | 275.1±30.1 °C |
Names
| Name | Loratadine |
|---|---|
| Synonym | More Synonyms |
Loratadine BiologicalActivity
| Description | Loratadine(SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.IC50 value: 32 uMTarget: H1-receptorLoratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Histamine ReceptorSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/Immunology |
| References | [1]. Kay GG, Harris AG. Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clin Exp Allergy. 1999 Jul;29 Suppl 3:147-50. [2]. Menardo JL, Horak F, Danzig MR, Czarlewski W. A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4. [3]. Monroe EW. Loratadine in the treatment of urticaria. Clin Ther. 1997 Mar-Apr;19(2):232-42. [4]. Haria M, Fitton A, Peters DH. Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders. Drugs. 1994 Oct;48(4):617-37. [5]. Roman IJ, Danzig MR. Loratadine. A review of recent findings in pharmacology, pharmacokinetics, efficacy, and safety, with a look at its use in combination with pseudoephedrine. Clin Rev Allergy. 1993 Spring;11(1):89-110. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 531.3±50.0 °C at 760 mmHg |
| Melting Point | 134-136°C |
| Molecular Formula | C22H23ClN2O2 |
| Molecular Weight | 382.883 |
| Flash Point | 275.1±30.1 °C |
| Exact Mass | 382.144806 |
| PSA | 42.43000 |
| LogP | 5.94 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.614 |
| InChIKey | JCCNYMKQOSZNPW-UHFFFAOYSA-N |
| SMILES | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 |
| Storage condition | 2-8°C |
| Stability | Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents. |
| Water Solubility | DMSO: 26 mg/mL, soluble |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles63
More Articles| Efficient HPLC method development using structure-based database search, physico-chemical prediction and chromatographic simulation. J. Pharm. Biomed. Anal. 104 , 49-54, (2014) Development of a robust HPLC method for pharmaceutical analysis can be very challenging and time-consuming. In our laboratory, we have developed a new workflow leveraging ACD/Labs software tools to im... | |
| Antihistamines modulate the integrin signaling pathway in h9c2 rat cardiomyocytes: Possible association with cardiotoxicity. Hum. Exp. Toxicol. 34 , 796-807, (2015) The identification of biomarkers for toxicity prediction is crucial for drug development and safety evaluation. The selective and specific biomarkers for antihistamines-induced cardiotoxicity is not w... | |
| Reliability of computer-assisted method transfer between several column dimensions packed with 1.3-5μm core-shell particles and between various instruments. J. Pharm. Biomed. Anal. 94 , 188-95, (2014) In this contribution, the possibility to automatically transfer RPLC methods between different column dimensions and instruments was evaluated using commercial modelling software. The method transfer ... |
Synonyms
| MFCD00672869 |
| ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate |
| CLARATYNE |
| Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate |
| Ethyl-4-(8-chlor-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yliden)piperidin-1-carboxylat |
| 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester |
| Loratadine |
| Flonidan |
| Claritine |
| Loranox |
| CLARITIN |
| Tadine |
| Klaritin |
| Civeran |
| Clarityn |
| Cronopen |
| Lisino |
| 11-[N-(Ethoxycarbonyl)-4-piperidylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine |
