CAS 473-15-4|beta-Eudesmol

Introduction：Basic information about CAS 473-15-4|beta-Eudesmol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. beta-Eudesmol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles27
7. Synonyms

Common Name	beta-Eudesmol
CAS Number	473-15-4	Molecular Weight	222.366
Density	1.0±0.1 g/cm3	Boiling Point	301.7±11.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₆O	Melting Point	72-74ºC
MSDS	ChineseUSA	Flash Point	108.6±15.6 °C

Names

Name	β-eudesmol
Synonym	More Synonyms

beta-Eudesmol BiologicalActivity

Description	Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1[1].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>Metabolic Disease
References	[1]. Ohara K, et al. β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system. Sci Rep. 2017 Nov 17;7(1):15785. [2]. Ohara K, et al. Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil. J Biol Chem. 2015 Jan 30;290(5):3161-71.

Description

Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1[1].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>Metabolic Disease

References

[1]. Ohara K, et al. β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system. Sci Rep. 2017 Nov 17;7(1):15785.

[2]. Ohara K, et al. Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil. J Biol Chem. 2015 Jan 30;290(5):3161-71.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	301.7±11.0 °C at 760 mmHg
Melting Point	72-74ºC
Molecular Formula	C₁₅H₂₆O
Molecular Weight	222.366
Flash Point	108.6±15.6 °C
Exact Mass	222.198364
PSA	20.23000
LogP	4.68
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.499
InChIKey	BOPIMTNSYWYZOC-VNHYZAJKSA-N
SMILES	C=C1CCCC2(C)CCC(C(C)(C)O)CC12
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ9698500

CHEMICAL NAME :: 2-Naphthalenemethanol, decahydro-8-methylene-alpha,alpha,4a-trimethyl-, (2R-(2-alpha,4a- alpha,8a-beta)-

CAS REGISTRY NUMBER :: 473-15-4

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H26-O

MOLECULAR WEIGHT :: 222.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #92-13629

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	QJ9698500

Articles27

Aroma evaluation of gamazumi (Viburnum dilatatum) by aroma extract dilution analysis and odour activity value.

Phytochem. Anal. 23(3) , 208-13, (2012)

Viburnum dilatatum (gamazumi) is widely distributed in Japan and China. Recently, juice from V. dilatatum fruits has been manufactured in Japan. Concerning the aroma of V. dilatatum, phenethyl alcohol...

Essential oil composition of Teucrium scordium L.

Acta. Pharm. 57(4) , 499-504, (2007)

Composition of the essential oil obtained from dried flowering aerial parts of Teucrium scordium L. (Labiatae) was analyzed by GC and GC/MS. Fifty-six components were identified in the essential oil o...

Composition and antimicrobial and anti-wood-decay fungal activities of the leaf essential oils of Machilus pseudolongifolia from Taiwan.

Nat. Prod. Commun. 5(7) , 1143-6, (2010)

The hydrodistillated leaf essential oil of Machilus pseudolongifolia was analyzed to determine its composition and yield. Seventy compounds were identified, the main components being beta-eudesmol (26...

Synonyms

2-[(2R,4aR,8aS)-4a-Methyl-8-methylenedecahydronaphthalen-2-yl]propan-2-ol

2-[(2R,4aR,8aS)-4a-methyl-8-methylidenedecahydronaphthalen-2-yl]propan-2-ol

Eudesm-4(14)-en-11-ol

2-[(2R,4aR,8aS)-4a-methyl-8-methylidene-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]propan-2-ol

b-Eudesmol

2-[(2R,4aR,8aS)-4a-Methyl-8-methylenedecahydro-2-naphthalenyl]-2-propanol

Eudesmol. B.

2-Naphthalenemethanol, decahydro-α,α,4a-trimethyl-8-methylene-, (2R,4aR,8aS)-

beta-eudesmol

(+)-b-Eudesmol

rel-2-[(2R,4aR,8aS)-4a-methyl-8-methylenedecahydronaphthalen-2-yl]propan-2-ol

|A-Eudesmol

Eudesm-4(14)-en-11-ol (8CI)

1,2a,3,4,4a,5,6,7,8,8aa-Decahydro-a,a,4ab-trimethyl-8-methylene-2-naphthalenemethanol

b-Selinenol

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