CAS 27262-48-2|Levobupivacaine hydrochloride

Introduction：Basic information about CAS 27262-48-2|Levobupivacaine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Levobupivacaine hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Levobupivacaine hydrochloride
CAS Number	27262-48-2	Molecular Weight	324.889
Density	/	Boiling Point	423.4ºC at 760 mmHg
Molecular Formula	C₁₈H₂₉ClN₂O	Melting Point	254 °C (dec.)(lit.)
MSDS	ChineseUSA	Flash Point	209.9ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	levobupivacaine hydrochloride (anhydrous)
Synonym	More Synonyms

Levobupivacaine hydrochloride BiologicalActivity

Description	Levobupivacaine Hcl is a local anaesthetic compound belonging to the amino amide group; long-acting local anesthetic.
Related Catalog	Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Metabolic Enzyme/Protease >>PhospholipaseResearch Areas >>Others
References	[1]. Burlacu CL, et al. Update on local anesthetics: focus on levobupivacaine. Ther Clin Risk Manag. 2008 Apr;4(2):381-92. [2]. Gulec D, et al. Intrathecal bupivacaine or levobupivacaine: which should be used for elderly patients? J Int Med Res. 2014 Apr;42(2):376-85.

Description

Levobupivacaine Hcl is a local anaesthetic compound belonging to the amino amide group; long-acting local anesthetic.

Related Catalog

Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Metabolic Enzyme/Protease >>PhospholipaseResearch Areas >>Others

References

[1]. Burlacu CL, et al. Update on local anesthetics: focus on levobupivacaine. Ther Clin Risk Manag. 2008 Apr;4(2):381-92.

[2]. Gulec D, et al. Intrathecal bupivacaine or levobupivacaine: which should be used for elderly patients? J Int Med Res. 2014 Apr;42(2):376-85.

Chemical & Physical Properties

Boiling Point	423.4ºC at 760 mmHg
Melting Point	254 °C (dec.)(lit.)
Molecular Formula	C₁₈H₂₉ClN₂O
Molecular Weight	324.889
Flash Point	209.9ºC
Exact Mass	324.196838
PSA	23.55000
LogP	4.74080
Vapour Pressure	2.24E-07mmHg at 25°C
InChIKey	SIEYLFHKZGLBNX-NTISSMGPSA-N
SMILES	CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK6120000

CHEMICAL NAME :: 2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride, (-)-

CAS REGISTRY NUMBER :: 27262-48-2

LAST UPDATED :: 198209

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H28-N2-O.Cl-H

MOLECULAR WEIGHT :: 324.94

WISWESSER LINE NOTATION :: T6NTJ A4 BVMR B1 F1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 207 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	T+: Very toxic;Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S22-S36/37/39-S45-S36/37-S53
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	TK6125000
HS Code	2942000000

Customs

HS Code	2942000000

Synonyms

levobupivacaine monohydrochloride

Levobupivacainehydrochloride

(S)-(-)-BUPIVACAINE HCL

Levobupivacaine Hydrochloride

L-BUPIVACAINE HYDROCHLORIDE

L-(-)-Bupivacaine

(S)-Bupivacaine hydrochloride

(RS)-bupivacaine hydrochloride

BUPIVACAINE HCL

Levobupivacaine HCl

bupivacaine.hydrochloride

MFCD01704265

(-)-Bupivacaine hydrochloride

Chirocaine

(2S)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride (1:1)

2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, (2S)-, hydrochloride (1:1)

1-butyl-piperidine-2-carboxylic acid-(2,6-dimethyl-anilide),hydrochloride

LEVAMISOLHCLSALT

(2S)-1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride (1:1)

(S)-(-)-Bupivacaine hydrochloride

(S)-Bupivacaine

(-)-Bupicaine Hydrochloride

bupicainehydrochloride(-)

Levobupivacaine (hydrochloride)

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