CAS 73465-43-7|1-Deoxymannojirimycin hydrochloride
Introduction：Basic information about CAS 73465-43-7|1-Deoxymannojirimycin hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-Deoxymannojirimycin hydrochloride | ||
|---|---|---|---|
| CAS Number | 73465-43-7 | Molecular Weight | 199.633 |
| Density | / | Boiling Point | / |
| Molecular Formula | C6H14ClNO4 | Melting Point | 183-185ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (+)-1-Deoxynojirimycin hydrochloride |
|---|---|
| Synonym | More Synonyms |
1-Deoxymannojirimycin hydrochloride BiologicalActivity
| Description | 1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusSignaling Pathways >>Anti-infection >>HIVResearch Areas >>Infection |
| Target | IC50: 20 μM (α1,2-mannosidase I)[1] N-linked glycosylation[2] HIV‐1[2] |
| References | [1]. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98. [2]. Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4. |
Chemical & Physical Properties
| Melting Point | 183-185ºC |
|---|---|
| Molecular Formula | C6H14ClNO4 |
| Molecular Weight | 199.633 |
| Exact Mass | 199.061142 |
| PSA | 92.95000 |
| Appearance of Characters | Powder | white to off-white |
| InChIKey | ZJIHMALTJRDNQI-MVNLRXSJSA-N |
| SMILES | Cl.OCC1NCC(O)C(O)C1O |
| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble10mg/mL |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | 22-24/25-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles1
More Articles| Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes. Glycobiology 6 , 413-421, (1996) The question whether or not target cell N-linked carbohydrate participates in cytotoxic T lymphocyte (CTL) mediated cytolysis has been in contention for well over a decade. Much of the evidence suppor... |
Synonyms
| (2R,3R,4R,5R)-3,4,5-Trihydroxy-2-(hydroxymethyl)piperidinium chloride |
| Piperidinium, 3,4,5-trihydroxy-2-(hydroxymethyl)-, chloride, (2R,3R,4R,5R)- (1:1) |
| 1-deoxymannojirimycin hydrochloride |
| (2R,3R,4R,5R)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride (1:1) |
