CAS 79183-19-0|Apoptosis Activator 2

Introduction：Basic information about CAS 79183-19-0|Apoptosis Activator 2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Apoptosis Activator 2 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Apoptosis Activator 2
CAS Number	79183-19-0	Molecular Weight	306.143
Density	1.5±0.1 g/cm3	Boiling Point	470.6±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₉Cl₂NO₂	Melting Point	/
MSDS	/	Flash Point	238.4±31.5 °C

Names

Name	1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
Synonym	More Synonyms

Apoptosis Activator 2 BiologicalActivity

Description	Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.IC50 value: 4-9 uM(Leukemia origin cells)[1]Target: Apoptosis activatorin vitro: Apoptosis Activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Apoptosis Activator 2 exerted a cytostatic effect on the majority of cell lines tested, inhibiting cell growth by 50–100% at 10 μM in 40 of 48 cell lines tested. Apoptosis Activator 2 exerted a cytotoxic effect, reducing the cell numbers by 10–50% and 50–100% in four and eight cell lines, respectively, from the initial levels when tested at 10 μM. At 100 μM Apoptosis Activator 2 exhibited 100% cytotoxicity in virtually all cell lines, an effect that may be due to nonspecific toxicity. Of the cancer cell lines tested in the panel, cell lines of lymphoid origin (CCRF-CEM, MOLT-4, and Jurkat) were quite sensitive to compound 2-induced killing, with IC50 values ranging from 4 to 9 μM [1]. Apoptosis Activator 2 is a potent and selective carboxylesterase inhibitor with Ki of 67/31/65 nM for hiCE/hCE/rCE respectively, also has less inhibition on AChE/BChE with Ki of 48.2/12.6 uM [2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer
References	[1]. Nguyen JT, et al. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8. [2]. Hyatt JL, et al. Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85.

Description

Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.IC50 value: 4-9 uM(Leukemia origin cells)[1]Target: Apoptosis activatorin vitro: Apoptosis Activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Apoptosis Activator 2 exerted a cytostatic effect on the majority of cell lines tested, inhibiting cell growth by 50–100% at 10 μM in 40 of 48 cell lines tested. Apoptosis Activator 2 exerted a cytotoxic effect, reducing the cell numbers by 10–50% and 50–100% in four and eight cell lines, respectively, from the initial levels when tested at 10 μM. At 100 μM Apoptosis Activator 2 exhibited 100% cytotoxicity in virtually all cell lines, an effect that may be due to nonspecific toxicity. Of the cancer cell lines tested in the panel, cell lines of lymphoid origin (CCRF-CEM, MOLT-4, and Jurkat) were quite sensitive to compound 2-induced killing, with IC50 values ranging from 4 to 9 μM [1]. Apoptosis Activator 2 is a potent and selective carboxylesterase inhibitor with Ki of 67/31/65 nM for hiCE/hCE/rCE respectively, also has less inhibition on AChE/BChE with Ki of 48.2/12.6 uM [2].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer

References

[1]. Nguyen JT, et al. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8.

[2]. Hyatt JL, et al. Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	470.6±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₉Cl₂NO₂
Molecular Weight	306.143
Flash Point	238.4±31.5 °C
Exact Mass	305.001038
PSA	37.38000
LogP	3.42
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.671
InChIKey	KGRJPLRFGLMQMV-UHFFFAOYSA-N
SMILES	O=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccccc21
Storage condition	Store at RT

Safety Information

Safety Phrases	24/25
RIDADR	3077
HS Code	29145090

Synonyms

1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-

Apoptosis Activator 2

Apoptosis Activator II

Tocris-2098

1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione

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