Introduction：Basic information about CAS 487-79-6|Kainic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kainic acid |
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| CAS Number | 487-79-6 | Molecular Weight | 213.230 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 439.9±45.0 °C at 760 mmHg |
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| Molecular Formula | C10H15NO4 | Melting Point | 253-254ºC |
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| MSDS | / | Flash Point | 219.8±28.7 °C |
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Names
| Name | kainic acid |
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| Synonym | More Synonyms |
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Kainic acid BiologicalActivity
| Description | Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS. |
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| Related Catalog | Signaling Pathways >>Others >>OthersNatural Products >>Acids and AldehydesResearch Areas >>Neurological Disease |
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| In Vivo | Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS. HO-I levels are significantly enhanced one, three and seven days after i.c.v, injection of Kainic acid. One day after i.c.v, injection of Kainic acid, the HO-I protein level reaches a maximum and then decreases, but is still significantly enhanced versus the vehicle-injected group. After i.c.v. injection of Kainic acid, HO-I-immunoreactivity is strongly induced not only in the CA3 but also widely in the whole hippocampus[1]. |
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| Animal Admin | The rats are fasted over night with free access to water. For stereotaxic injection, rats are anaesthetized (sodium pentobarbital, 50 mg/kg, i.p.) and immobilized in a Kopf stereotaxic frame. The rats are microinjected with 1 μg Kainic acid in 2 μL of sterilized physiological saline into the right lateral ventricle, i.e., 0.2 mm caudal from the bregma, 1.2 mm right lateral and 3.8 mm ventral according to the rat brain atlas. For control, rats are injected with same amount (2 μL) of vehicle, sterilized physiological saline. Five rats in each group are used in this study[1]. |
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| References | [1]. Matsuoka Y, et al. Kainic acid induction of heme oxygenase in vivo and in vitro. Neuroscience. 1998 Aug;85(4):1223-33. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 439.9±45.0 °C at 760 mmHg |
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| Melting Point | 253-254ºC |
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| Molecular Formula | C10H15NO4 |
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| Molecular Weight | 213.230 |
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| Flash Point | 219.8±28.7 °C |
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| Exact Mass | 213.100113 |
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| PSA | 86.63000 |
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| LogP | 0.50 |
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| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
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| Index of Refraction | 1.509 |
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| InChIKey | VLSMHEGGTFMBBZ-UHFFFAOYSA-N |
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| SMILES | C=C(C)C1CNC(C(=O)O)C1CC(=O)O |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UX9665250
- CHEMICAL NAME :
- 3-Pyrrolidineacetic acid, 2-carboxy-4-isopropenyl-
- CAS REGISTRY NUMBER :
- 487-79-6
- BEILSTEIN REFERENCE NO. :
- 0086660
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C10-H15-N-O4
- MOLECULAR WEIGHT :
- 213.26
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 3 mg/kg
- SEX/DURATION :
- female 14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 3 mg/kg
- SEX/DURATION :
- female 17-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 3 mg/kg
- SEX/DURATION :
- female 19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 12 mg/kg
- REFERENCE :
- FOBGA8 Folia Biologica (Krakow). (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1953- Volume(issue)/page/year: 36,103,1988
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | 22-24/25-36 |
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| RTECS | UX9665250 |
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Synonyms
| KAINATE |
| helminal |
| kainic acid |
| Kainic |
| digenin |
| Dihydroergocristine mesylate |
| (3S,4S)-3-(Carboxymethyl)-4-isopropenyl-L-proline |
| digenicacid |
| (−)-Kainic Acid |
| L-Proline, 3-(carboxymethyl)-4-(1-methylethenyl)-, (3S,4S)- |
