Introduction：Basic information about CAS 178803-51-5|SNC 162, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SNC 162 |
|---|
| CAS Number | 178803-51-5 | Molecular Weight | 419.60 |
|---|
| Density | 1.027g/cm3 | Boiling Point | 536.4ºC at 760mmHg |
|---|
| Molecular Formula | C27H37N3O | Melting Point | / |
|---|
| MSDS | / | Flash Point | 202.4ºC |
|---|
Names
| Name | 4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide |
|---|
| Synonym | More Synonyms |
|---|
SNC 162 BiologicalActivity
| Description | SNC162 is a delta-opioid receptor agonist with an IC50 of 0.94 nM. SNC162 has antidepressant-like effects and produces a selective enhancement of the antinociceptive effects of fentanyl in rhesus monkeys[1][2]. |
|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease |
|---|
| Target | IC50: 0.94 nM (delta-opioid receptor)[1] |
|---|
| References | [1]. Jutkiewicz EM, et al. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. J Pharmacol Exp Ther. 2004 Apr;309(1):173-81. [2]. Banks ML, et al. Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics. Pharmacol Biochem Behav. 2010 Dec;97(2):205-12. |
|---|
Chemical & Physical Properties
| Density | 1.027g/cm3 |
|---|
| Boiling Point | 536.4ºC at 760mmHg |
|---|
| Molecular Formula | C27H37N3O |
|---|
| Molecular Weight | 419.60 |
|---|
| Flash Point | 202.4ºC |
|---|
| Exact Mass | 419.29400 |
|---|
| PSA | 26.79000 |
|---|
| LogP | 4.71440 |
|---|
| Vapour Pressure | 1.4E-11mmHg at 25°C |
|---|
| Index of Refraction | 1.549 |
|---|
| InChIKey | WGIDFDFAOQVAHY-UFPGJGBJSA-N |
|---|
| SMILES | C=CCN1CC(C)N(C(c2ccccc2)c2ccc(C(=O)N(CC)CC)cc2)CC1C |
|---|
Synonyms
