Introduction：Basic information about CAS 490-75-5|HOMOQUINOLINIC ACID, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | HOMOQUINOLINIC ACID |
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| CAS Number | 490-75-5 | Molecular Weight | 181.15 |
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| Density | 1.477g/cm3 | Boiling Point | 437ºC at 760mmHg |
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| Molecular Formula | C8H7NO4 | Melting Point | / |
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| MSDS | / | Flash Point | 218.1ºC |
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Names
| Name | 3-(carboxymethyl)pyridine-2-carboxylic acid |
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| Synonym | More Synonyms |
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HOMOQUINOLINIC ACID BiologicalActivity
| Description | Homoquinolinic acid is a non endogenous agonist of NMDAR2 receptor[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
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| In Vitro | Homoquinolinic acid (HQA，20 μM) 导致在第V层记录的事件频率显著增加[2]。 Homoquinolinic acid (HQA) 作用于突触前端，增强谷氨酸的释放[2]。 |
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| References | [1]. L P de Carvalho, et al. The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem Int. 1996 Apr;28(4):445-52. [2]. G Woodhall, et al. NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. J Neurophysiol. 2001 Oct;86(4):1644-51. |
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Chemical & Physical Properties
| Density | 1.477g/cm3 |
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| Boiling Point | 437ºC at 760mmHg |
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| Molecular Formula | C8H7NO4 |
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| Molecular Weight | 181.15 |
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| Flash Point | 218.1ºC |
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| Exact Mass | 181.03800 |
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| PSA | 87.49000 |
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| LogP | 0.40690 |
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| Vapour Pressure | 2.07E-08mmHg at 25°C |
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| Index of Refraction | 1.607 |
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| InChIKey | HQPMJFFEXJELOQ-UHFFFAOYSA-N |
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| SMILES | O=C(O)Cc1cccnc1C(=O)O |
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Synonyms
| Homoquinolinate |
| Bromocriptine mesylate |
| Homoquinolinic acid |
| Tocris-0197 |
