CAS 293754-55-9|T0901317
| Common Name | T0901317 | ||
|---|---|---|---|
| CAS Number | 293754-55-9 | Molecular Weight | 481.333 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 470.5±55.0 °C at 760 mmHg |
| Molecular Formula | C17H12F9NO3S | Melting Point | 116-122° C |
| MSDS | USA | Flash Point | 238.4±31.5 °C |
Names
| Name | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide |
|---|---|
| Synonym | More Synonyms |
T0901317 BiologicalActivity
| Description | T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>FXRSignaling Pathways >>Metabolic Enzyme/Protease >>LXRResearch Areas >>Cancer |
| References | [1]. Ding H et al. LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor?κB. Mol Med Rep. 2016 Jun;13(6):4888-96 [2]. Baranowski M et al. Insulin-sensitizing effect of LXR agonist T0901317 in high-fat fed rats is associated with restored muscle GLUT4 expression and insulin-stimulated AS160 phosphorylation. Cell Physiol Biochem. 2014;33(4):1047-5 |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 470.5±55.0 °C at 760 mmHg |
| Melting Point | 116-122° C |
| Molecular Formula | C17H12F9NO3S |
| Molecular Weight | 481.333 |
| Flash Point | 238.4±31.5 °C |
| Exact Mass | 481.039429 |
| PSA | 65.99000 |
| LogP | 4.82 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.491 |
| InChIKey | SGIWFELWJPNFDH-UHFFFAOYSA-N |
| SMILES | O=S(=O)(c1ccccc1)N(CC(F)(F)F)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles11
More Articles| Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport. J. Nutr. Biochem. 26(2) , 165-72, (2015) High-density lipoproteins (HDLs) are atheroprotective because of their role in reverse cholesterol transport. The intestine is involved in this process because it synthesizes HDL, removes cholesterol ... | |
| RNA binding protein HuR regulates the expression of ABCA1. J. Lipid Res. 55(6) , 1066-1076, (2014) ABCA1 is a major regulator of cellular cholesterol efflux and plasma HDL biogenesis. Even though the transcriptional activation of ABCA1 is well established, the posttranscriptional regulation of ABCA... | |
| Effect of compounds affecting ABCA1 expression and CETP activity on the HDL pathway involved in intestinal absorption of lutein and zeaxanthin. Lipids 49(12) , 1233-43, (2014) The antioxidant xanthophylls lutein and zeaxanthin are absorbed from the diet in a process involving lipoprotein formation. Selective mechanisms exist for their intestinal uptake and tissue-selective ... |
Synonyms
| N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE |
| Benzenesulfonamide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]- |
| N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide |
| MFCD03412028 |
| N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide |
| T0901317 |
