CAS 324029-01-8|AKTide-2T TFA

Introduction：Basic information about CAS 324029-01-8|AKTide-2T TFA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. AKTide-2T TFA BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	AKTide-2T TFA
CAS Number	324029-01-8	Molecular Weight	1715.87000
Density	/	Boiling Point	/
Molecular Formula	C₇₄H₁₁₄N₂₈O₂₀	Melting Point	153-156ºC
MSDS	/	Flash Point	/

Names

Name	AKTide-2T
Synonym	More Synonyms

AKTide-2T TFA BiologicalActivity

Description	AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>PI3K/Akt/mTOR >>Akt
Target	Akt
In Vitro	AKTide-2T mimics the optimal phosphorylation sequence of Akt, and inhibits Akt phosphorylated Hsp27 by addition of 20 μM Akt inhibitory peptide[1].
References	[1]. T Obata,et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17;275(46):36108-15. [2]. Madhavi J Rane, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003 Jul 25;278(30):27828-35.

Chemical & Physical Properties

Melting Point	153-156ºC
Molecular Formula	C₇₄H₁₁₄N₂₈O₂₀
Molecular Weight	1715.87000
Exact Mass	1714.88000
PSA	808.69000
LogP	0.70630
InChIKey	HSEMWALZGKQWLK-SWWIKBNJSA-N
SMILES	CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CO)C(=O)NC(Cc1ccccc1)C(=O)NCC(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(C)C(=O)O)C(C)O
Storage condition	-20°C

Synonyms

ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA

ARKRERTYSFGHHA

H-ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA-OH

AKT/PKB/Rac-Protein Kinase Substrate

Substrate for AKT/PKB/Rac-protein Kinase

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