Introduction：Basic information about CAS 58546-34-2|Cucurbitacin IIA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cucurbitacin IIA |
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| CAS Number | 58546-34-2 | Molecular Weight | 562.735 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 679.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C32H50O8 | Melting Point | / |
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| MSDS | / | Flash Point | 209.7±25.0 °C |
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Names
| Name | [(6R)-6-hydroxy-2-methyl-5-oxo-6-[(2S,3S,8S,9R,10R,13R,14S,16R,17R)-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-11-oxo-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]heptan-2-yl] acetate |
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| Synonym | More Synonyms |
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Cucurbitacin IIA BiologicalActivity
| Description | Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Apoptosis >>Survivin |
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| References | [1]. Boykin C, et al. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. Br J Cancer. 2011 Mar 1;104(5):781-9. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 679.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C32H50O8 |
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| Molecular Weight | 562.735 |
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| Flash Point | 209.7±25.0 °C |
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| Exact Mass | 562.350586 |
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| PSA | 141.36000 |
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| LogP | 2.82 |
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| Vapour Pressure | 0.0±4.8 mmHg at 25°C |
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| Index of Refraction | 1.564 |
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| InChIKey | LKYNAQSYQLFTCM-GYXNDICUSA-N |
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| SMILES | CC(=O)OC(C)(C)CCC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(O)C4(C)C)C3(C)C(=O)CC12C |
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| Storage condition | -20℃ |
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Safety Information
Synonyms
| 23,24-Dihydrocucurbitacin F-25-O-acetate |
| 19-Norlanost-5-ene-11,22-dione, 25-(acetyloxy)-2,3,16,20-tetrahydroxy-9-methyl-, (2β,3α,9β,10α,16α)- |
| Curcurbitacin Q1 |
| (1S,2S,4R,9β,16α)-1,2,16,20-Tetrahydroxy-9,10,14-trimethyl-11,22-dioxo-4,9-cyclo-9,10-secocholest-5-en-25-yl acetate |
| Estr-5-en-11-one, 17-[(1R)-5-(acetyloxy)-1-hydroxy-1,5-dimethyl-2-oxohexyl]-2,3,16-trihydroxy-4,4,9,14-tetramethyl-, (2β,3α,9β,10α,16α,17β)- |
| Dihydrocucurbitacin F 25-O-acetate |
| X1160 |
| Dihydrocucurbitacin Q1 |
| 25-O-Acetyl-23,24-dihydrocucurbitacin F |
| Cucurbitacin IIa |
| Hemslecin A |
