CAS 636-61-3|D-(+)-Malic acid
| Common Name | D-(+)-Malic acid | ||
|---|---|---|---|
| CAS Number | 636-61-3 | Molecular Weight | 134.087 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 306.4±27.0 °C at 760 mmHg |
| Molecular Formula | C4H6O5 | Melting Point | 98-104ºC |
| MSDS | ChineseUSA | Flash Point | 153.4±20.2 °C |
| Symbol | GHS05, GHS07 | Signal Word | Danger |
Names
| Name | (R)-malic acid |
|---|---|
| Synonym | More Synonyms |
D-(+)-Malic acid BiologicalActivity
| Description | D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| In Vitro | Some bacteria belonging to Arthrobacter, Brevibacterium, Corynebacterium, Pseudomonas, Bacillus, and Acinetobacter produced D-(+)-Malic acid (D-Malic acid) from Maleic acid when the cells grown in a medium containing citraconic acid are reacted aerobically with Maleic acid in the pH 7.0 phosphate buffer containing 0.1% sodium chloride[2]. |
| References | [1]. Manuela Côrte-Real, et al. Transport of L(-)malic acid and other dicarboxylic acids in the yeast Candida sphaerica. Appl Microbiol Biotechnol (1989) 31:551-555. [2]. Kiyoshi Nakayama, et al. D-malic acid production from maleic acid using microorganism: Screening of microorganism. Biotechnology Letters volume 15, 271–276(1993). |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 306.4±27.0 °C at 760 mmHg |
| Melting Point | 98-104ºC |
| Molecular Formula | C4H6O5 |
| Molecular Weight | 134.087 |
| Flash Point | 153.4±20.2 °C |
| Exact Mass | 134.021530 |
| PSA | 94.83000 |
| LogP | -1.26 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.529 |
| InChIKey | BJEPYKJPYRNKOW-UWTATZPHSA-N |
| SMILES | O=C(O)CC(O)C(=O)O |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year: 15,628,1923
Safety Information
| Symbol | GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H318-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | ON7260000 |
| HS Code | 29181980 |
Customs
| HS Code | 2918199090 |
|---|---|
| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| Malic acid, D- |
| (R)-Hydroxybutanedioic acid |
| Butanedioic acid, 2-hydroxy-, (2R)- |
| EINECS 211-262-2 |
| (R)-(+)-HYDROXYSUCCINIC ACID |
| Malic acid,D |
| R-Malic acid |
| D-malate |
| D-Malic Acid |
| (R)-2-Hydroxysuccinic acid |
| (R)-2-Hydroxy-succinic acid |
| (2R)-2-hydroxybutanedioic acid |
| 2(R)-hydroxybutanedioic acid |
| (2R)-2-Hydroxysuccinic acid |
| L-malic acid |
| (R)-malic acid |
| D-(+)-Malic Acid |
| D-Hydroxybutanedioic acid |
| MFCD00004245 |
| D(+)-Malic acid |
