Introduction：Basic information about CAS 45120-30-7|H-Glu-OtBu, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-Glu-OtBu |
|---|
| CAS Number | 45120-30-7 | Molecular Weight | 203.236 |
|---|
| Density | 1.1±0.1 g/cm3 | Boiling Point | 326.8±32.0 °C at 760 mmHg |
|---|
| Molecular Formula | C9H17NO4 | Melting Point | 140ºC |
|---|
| MSDS | / | Flash Point | 151.5±25.1 °C |
|---|
Names
| Name | (S)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid |
|---|
| Synonym | More Synonyms |
|---|
H-Glu-OtBu BiologicalActivity
| Description | H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
|---|
| Target | Non-cleavable |
|---|
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
|---|
| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
|---|
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|
| Boiling Point | 326.8±32.0 °C at 760 mmHg |
|---|
| Melting Point | 140ºC |
|---|
| Molecular Formula | C9H17NO4 |
|---|
| Molecular Weight | 203.236 |
|---|
| Flash Point | 151.5±25.1 °C |
|---|
| Exact Mass | 203.115753 |
|---|
| PSA | 89.62000 |
|---|
| LogP | 0.77 |
|---|
| Appearance of Characters | Powder | White |
|---|
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
|---|
| Index of Refraction | 1.476 |
|---|
| InChIKey | QVAQMUAKTNUNLN-LURJTMIESA-N |
|---|
| SMILES | CC(C)(C)OC(=O)C(N)CCC(=O)O |
|---|
| Storage condition | Store at 0°C |
|---|
Safety Information
| Hazard Codes | Xi |
|---|
| HS Code | 2922509090 |
|---|
Customs
| HS Code | 2922509090 |
|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|---|
Synonyms
| L-Glutamic acid, 1-(1,1-dimethylethyl) ester |
| L-Glutamic acid α-tert·butyl ester |
| (4S)-4-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoic acid |
| (4S)-4-Amino-5-tert-butoxy-5-oxopentanoic acid (non-preferred name) |
| H-Glu-OtBu |
