Introduction：Basic information about CAS 474-74-8|Glycolithocholic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Glycolithocholic acid |
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| CAS Number | 474-74-8 | Molecular Weight | 433.62400 |
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| Density | 1.112g/cm3 | Boiling Point | 619.7ºC at 760mmHg |
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| Molecular Formula | C26H43NO4 | Melting Point | 212-214°C (lit.) |
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| MSDS | / | Flash Point | 328.6ºC |
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Names
| Name | glycolithocholic acid |
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| Synonym | More Synonyms |
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Glycolithocholic acid BiologicalActivity
| Description | Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC)[1][2][3][4]. |
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| Related Catalog | Research Areas >>Inflammation/Immunology |
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| In Vivo | The concentrations of Glycolithocholic acid in ulcerative colitis (UC) patients were significantly lower than those in healthy controls (HCs)[2]. |
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| References | [1]. Tanno N, et, al. Biliary lipid composition in heterozygous familial hypercholesterolemia and influence of treatment with probucol. Dig Dis Sci. 1994 Jul;39(7):1586-91. [2]. Ang ZH, et, al. Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis. World J Gastroenterol. 2021 Jun 28;27(24):3609-3629. [3]. Bansal S, et, al. Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites. J Pharmacol Exp Ther. 2019 Jun;369(3):389-405. [4]. Sanyal AJ, et, al. Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases. JHEP Rep. 2021 Feb 19;3(3):100255. |
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Chemical & Physical Properties
| Density | 1.112g/cm3 |
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| Boiling Point | 619.7ºC at 760mmHg |
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| Melting Point | 212-214°C (lit.) |
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| Molecular Formula | C26H43NO4 |
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| Molecular Weight | 433.62400 |
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| Flash Point | 328.6ºC |
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| Exact Mass | 433.31900 |
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| PSA | 86.63000 |
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| LogP | 5.01420 |
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| InChIKey | XBSQTYHEGZTYJE-OETIFKLTSA-N |
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| SMILES | CC(CCC(=O)NCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MC0594200
- CHEMICAL NAME :
- Glycine, N-((3-alpha,5-beta)-3-hydroxy-24-oxocholan-24-yl)-
- CAS REGISTRY NUMBER :
- 474-74-8
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C26-H43-N-O4
- MOLECULAR WEIGHT :
- 433.70
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,1911,1994
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Safety Information
Synonyms
| Glycolithocholic acid |
| 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid |
| Lithocholic acid glycine conjugate |
| Lithocholylglycine |
| Glycolithocholate |
